Emerging roles for the autophagy machinery in extracellular vesicle biogenesis and secretion.

Autor: Leidal AM; Department of Pathology and Helen Diller Family Comprehensive Cancer Center University of California San Francisco San Francisco CA USA., Debnath J; Department of Pathology and Helen Diller Family Comprehensive Cancer Center University of California San Francisco San Francisco CA USA.
Jazyk: angličtina
Zdroj: FASEB bioAdvances [FASEB Bioadv] 2021 Mar 02; Vol. 3 (5), pp. 377-386. Date of Electronic Publication: 2021 Mar 02 (Print Publication: 2021).
DOI: 10.1096/fba.2020-00138
Abstrakt: Autophagy classically functions to maintain cell health during stressful conditions by targeting cytosolic components for degradation and recycling via lysosomal pathways. However, accumulating evidence also supports roles for autophagy-related genes (ATGs) in non-degradative processes including cellular secretion. Here, we review emerging roles for the autophagy machinery in regulating extracellular vesicle loading and secretion and discuss how functional coupling of these pathways may impact normal physiology and disease.
Competing Interests: JD is the member of the Scientific Advisory Board of Vescor Therapeutics, LLC.
(© 2021 The Authors. FASEB BioAdvances published by the Federation of American Societies for Experimental Biology.)
Databáze: MEDLINE
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