Molecular engineering of piezoelectricity in collagen-mimicking peptide assemblies.

Autor: Bera S; George S. Wise Faculty of Life Sciences, Shmunis School of Biomedicine and Cancer Research, Tel Aviv University, Ramat Aviv, Israel., Guerin S; Department of Physics, Bernal Institute, University of Limerick, Limerick, Ireland., Yuan H; School of Advanced Materials and Nanotechnology, Xidian University, Xi'an, China., O'Donnell J; Department of Physics, Bernal Institute, University of Limerick, Limerick, Ireland., Reynolds NP; ARC Training Centre in Biodevices, Faculty of Science, Engineering and Technology, Swinburne University of Technology, Melbourne, Victoria, Australia.; Department of Chemistry and Physics, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, Victoria, Australia., Maraba O; Department of Physics, Bernal Institute, University of Limerick, Limerick, Ireland., Ji W; George S. Wise Faculty of Life Sciences, Shmunis School of Biomedicine and Cancer Research, Tel Aviv University, Ramat Aviv, Israel., Shimon LJW; Department of Chemical Research Support, Weizmann Institute of Science, Rehovot, Israel., Cazade PA; Department of Physics, Bernal Institute, University of Limerick, Limerick, Ireland., Tofail SAM; Department of Physics, Bernal Institute, University of Limerick, Limerick, Ireland., Thompson D; Department of Physics, Bernal Institute, University of Limerick, Limerick, Ireland. Damien.Thompson@ul.ie., Yang R; School of Advanced Materials and Nanotechnology, Xidian University, Xi'an, China. rsyang@xidian.edu.cn., Gazit E; George S. Wise Faculty of Life Sciences, Shmunis School of Biomedicine and Cancer Research, Tel Aviv University, Ramat Aviv, Israel. ehudg@post.tau.ac.il.
Jazyk: angličtina
Zdroj: Nature communications [Nat Commun] 2021 May 11; Vol. 12 (1), pp. 2634. Date of Electronic Publication: 2021 May 11.
DOI: 10.1038/s41467-021-22895-6
Abstrakt: Realization of a self-assembled, nontoxic and eco-friendly piezoelectric device with high-performance, sensitivity and reliability is highly desirable to complement conventional inorganic and polymer based materials. Hierarchically organized natural materials such as collagen have long been posited to exhibit electromechanical properties that could potentially be amplified via molecular engineering to produce technologically relevant piezoelectricity. Here, by using a simple, minimalistic, building block of collagen, we fabricate a peptide-based piezoelectric generator utilising a radically different helical arrangement of Phe-Phe-derived peptide, Pro-Phe-Phe and Hyp-Phe-Phe, based only on proteinogenic amino acids. The simple addition of a hydroxyl group increases the expected piezoelectric response by an order of magnitude (d 35  = 27 pm V -1 ). The value is highest predicted to date in short natural peptides. We demonstrate tripeptide-based power generator that produces stable max current >50 nA and potential >1.2 V. Our results provide a promising device demonstration of computationally-guided molecular engineering of piezoelectricity in peptide nanotechnology.
Databáze: MEDLINE
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