Vaccination as a possible trigger for immune-mediated necrotising myopathy.

Autor:	Cavalcanti JFB; Laboratory of Neuromuscular Disease, Department of Neurosciences, Centro Universitário FMABC, Santo Andre, Brazil., Silva MBA; Centro Universitário FMABC, Santo Andre, SP, Brazil., Alves de Siqueira Carvalho A; Laboratory of Neuromuscular Disease, Department of Neurosciences, Centro Universitário FMABC, Santo Andre, Brazil alzirasiqueiracarvalho@gmail.com.
Jazyk:	angličtina
Zdroj:	BMJ case reports [BMJ Case Rep] 2021 May 11; Vol. 14 (5). Date of Electronic Publication: 2021 May 11.
DOI:	10.1136/bcr-2021-242095
Abstrakt:	Immune-mediated necrotising myopathy is a rare autoimmune myopathy characterised by severe progressive muscle weakness, elevated levels of creatine kinase (CK), and necrosis with minimal inflammatory cell infiltration on muscle biopsy. We report a case of a previously healthy 42-year-old woman who presented with progressive muscle weakness 2 weeks after immunisation for yellow fever, tetanus/diphtheria and hepatitis B. Her symptoms started from the lower limbs and progressed to the upper limbs and cervical region associated with dysphagia, making her wheelchair bound. Electromyography showed a myopathic pattern, with a CK level of 12.177 U/L (reference value: 26-190 U/L), and biceps brachial muscle biopsy confirmed necrosis and regeneration fibres. The immunoblot test was positive for antisignal recognition particle. She was successfully treated with prednisone (1 mg/kg/day). Although considered safe, vaccines may cause allergic reactions or trigger autoimmune disorders. Currently, a causal relationship between them cannot be established. Competing Interests: Competing interests: None declared. (© BMJ Publishing Group Limited 2021. No commercial re-use. See rights and permissions. Published by BMJ.)
Databáze:	MEDLINE
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