Plasticity of stereotyped birdsong driven by chronic manipulation of cortical-basal ganglia activity.

Autor:	Moorman S; Psychology Department, Utrecht University, Yalelaan 2, 3584 CM Utrecht, the Netherlands; Biology Department, Tufts University, 200 Boston Avenue, Medford, MA 02155, USA. Electronic address: s.moorman@uu.nl., Ahn JR; Biology Department, Tufts University, 200 Boston Avenue, Medford, MA 02155, USA., Kao MH; Biology Department, Tufts University, 200 Boston Avenue, Medford, MA 02155, USA; Neuroscience Graduate Program, Tufts University, Boston, MA 02111, USA. Electronic address: mimi.kao@tufts.edu.
Jazyk:	angličtina
Zdroj:	Current biology : CB [Curr Biol] 2021 Jun 21; Vol. 31 (12), pp. 2619-2632.e4. Date of Electronic Publication: 2021 May 10.
DOI:	10.1016/j.cub.2021.04.030
Abstrakt:	Cortical-basal ganglia (CBG) circuits are critical for motor learning and performance, and are a major site of pathology. In songbirds, a CBG circuit regulates moment-by-moment variability in song and also enables song plasticity. Studies have shown that variable burst firing in LMAN, the output nucleus of this CBG circuit, actively drives acute song variability, but whether and how LMAN drives long-lasting changes in song remains unclear. Here, we ask whether chronic pharmacological augmentation of LMAN bursting is sufficient to drive plasticity in birds singing stereotyped songs. We show that altered LMAN activity drives cumulative changes in acoustic structure, timing, and sequencing over multiple days, and induces repetitions and silent pauses reminiscent of human stuttering. Changes persisted when LMAN was subsequently inactivated, indicating plasticity in song motor regions. Following cessation of pharmacological treatment, acoustic features and song sequence gradually recovered to their baseline values over a period of days to weeks. Together, our findings show that augmented bursting in CBG circuitry drives plasticity in well-learned motor skills, and may inform treatments for basal ganglia movement disorders. Competing Interests: Declaration of interests The authors declare no competing interests. (Copyright © 2021 The Authors. Published by Elsevier Inc. All rights reserved.)
Databáze:	MEDLINE
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