Nanosilver and Silver Nitrate Toxicity in Ex Vivo-Exposed Gills of Fish and Mitigation by Humic Acids.

Autor: Ale A; Instituto Nacional de Limnología, UNL, CONICET, Santa Fe, Argentina. ale.analia@gmail.com., Galdopórpora JM; Facultad de Farmacia y Bioquímica, Instituto de la Química y Metabolismo del Fármaco (IQUIMEFA), Universidad de Buenos Aires, CONICET, Buenos Aires, Argentina., Desimone MF; Facultad de Farmacia y Bioquímica, Instituto de la Química y Metabolismo del Fármaco (IQUIMEFA), Universidad de Buenos Aires, CONICET, Buenos Aires, Argentina., de la Torre FR; GECAP, Departamento de Ciencias Básicas e INEDES, Universidad Nacional de Luján, CONICET, Luján, Argentina., Cazenave J; Instituto Nacional de Limnología, UNL, CONICET, Santa Fe, Argentina.; Facultad de Humanidades y Ciencias, UNL, Santa Fe, Argentina.
Jazyk: angličtina
Zdroj: Bulletin of environmental contamination and toxicology [Bull Environ Contam Toxicol] 2021 Sep; Vol. 107 (3), pp. 421-426. Date of Electronic Publication: 2021 May 11.
DOI: 10.1007/s00128-021-03257-w
Abstrakt: Silver nanoparticles (AgNP) are unique because of their biocide properties. Once released to environment, AgNP interact with the natural organic matter which impact on their fate, dispersion, and ultimate toxicity. We carried out an ex vivo exposure of gill of Corydoras paleatus fish to 100 µg L -1 of AgNP or AgNO 3 , alone and in combination with 10 mg L -1 of humic acids (HA), with the aim to evaluate the potential mitigation of HA on AgNP toxic effects. We analyzed Ag accumulation and oxidative stress biomarkers. The results showed high bioaccumulation after the AgNO 3 +HA exposure. An inhibition of glutathione-S-transferase enzymatic activity and depletion of reduced glutathione levels were registered after the AgNO 3 exposure, and increased lipid peroxidation levels in the case of AgNP one. Oxidative responses were mitigated when the HA were present in the media. Overall, the knowledge about the fate of this emergent pollutant was deepened through this study.
(© 2021. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)
Databáze: MEDLINE
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