Anti-obesity properties and mechanism of action of flavonoids: A review.

Autor:	Oliveira AKS; Multiuser Health Center Facility (CMulti-Saúde), Aracaju, SE, Brazil.; Health Sciences Graduate Program (PPGCS), Federal University of Sergipe, Aracaju, SE, Brazil., de Oliveira E Silva AM; Health Sciences Graduate Program (PPGCS), Federal University of Sergipe, Aracaju, SE, Brazil.; Department of Nutrition, Federal University of Sergipe, UFS, São Cristóvão, SE, Brazil., Pereira RO; Department of Nutrition, Federal University of Sergipe, UFS, São Cristóvão, SE, Brazil., Santos AS; Department of Nutrition, Federal University of Sergipe, UFS, São Cristóvão, SE, Brazil., Barbosa Junior EV; Department of Nutrition, Federal University of Sergipe, UFS, São Cristóvão, SE, Brazil., Bezerra MT; Multiuser Health Center Facility (CMulti-Saúde), Aracaju, SE, Brazil.; Health Sciences Graduate Program (PPGCS), Federal University of Sergipe, Aracaju, SE, Brazil., Barreto RSS; Multiuser Health Center Facility (CMulti-Saúde), Aracaju, SE, Brazil.; Health Sciences Graduate Program (PPGCS), Federal University of Sergipe, Aracaju, SE, Brazil., Quintans-Junior LJ; Multiuser Health Center Facility (CMulti-Saúde), Aracaju, SE, Brazil.; Health Sciences Graduate Program (PPGCS), Federal University of Sergipe, Aracaju, SE, Brazil.; Department of Physiology, Aracaju, SE, Brazil., Quintans JSS; Multiuser Health Center Facility (CMulti-Saúde), Aracaju, SE, Brazil.; Health Sciences Graduate Program (PPGCS), Federal University of Sergipe, Aracaju, SE, Brazil.; Department of Physiology, Aracaju, SE, Brazil.
Jazyk:	angličtina
Zdroj:	Critical reviews in food science and nutrition [Crit Rev Food Sci Nutr] 2022; Vol. 62 (28), pp. 7827-7848. Date of Electronic Publication: 2021 May 10.
DOI:	10.1080/10408398.2021.1919051
Abstrakt:	Obesity is a major public health problem, and there is increasing scientific interest in its mechanisms, as well as a search for new compounds with antioxidant and anti-inflammatory properties that can minimize the metabolic complications associated with its pathology. One potential source of these compounds is natural products; Among these, flavonoids are a promising group of natural substances. Flavonoids are active constituents with diverse biological activities and are widely found in plants kingdom. Numerous studies have shown that flavonoids can effectively inhibit obesity and related metabolic disorders. The review synthesizes recent evidence in respect of progress in the understanding of the anti-obesity effects of flavonoids. Such effects which occurs through the modulation of proteins, genes and transcriptional factors involved in decreasing lipogenesis, increasing lipolysis, expenditure energy, stimulating fatty acids B-oxidation, digestion and metabolism of carbohydrates. In addition to mitigating inflammatory responses and suppress oxidative stress. A better understanding of the modulating effects and mechanisms of flavonoids in relation to obesity will allow us to better use these compounds to treat or even prevent obesity and its associated comorbidities.
Databáze:	MEDLINE
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