Recovery of consciousness and cognition after general anesthesia in humans.

Autor:	Mashour GA; Center for Consciousness Science, Department of Anesthesiology, University of Michigan Medical School, Ann Arbor, United States., Palanca BJ; Department of Anesthesiology, Washington University School of Medicine, St. Louis, United States., Basner M; Department of Anesthesiology and Critical Care, Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States., Li D; Center for Consciousness Science, Department of Anesthesiology, University of Michigan Medical School, Ann Arbor, United States., Wang W; Department of Mathematics and Statistics, Washington University, St. Louis, United States., Blain-Moraes S; Center for Consciousness Science, Department of Anesthesiology, University of Michigan Medical School, Ann Arbor, United States., Lin N; Department of Mathematics and Statistics, Washington University, St. Louis, United States., Maier K; Department of Anesthesiology and Critical Care, Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States., Muench M; Department of Anesthesiology, Washington University School of Medicine, St. Louis, United States., Tarnal V; Center for Consciousness Science, Department of Anesthesiology, University of Michigan Medical School, Ann Arbor, United States., Vanini G; Center for Consciousness Science, Department of Anesthesiology, University of Michigan Medical School, Ann Arbor, United States., Ochroch EA; Department of Anesthesiology and Critical Care, Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States., Hogg R; Department of Anesthesiology and Critical Care, Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States., Schwartz M; Department of Anesthesiology and Critical Care, Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States., Maybrier H; Department of Anesthesiology, Washington University School of Medicine, St. Louis, United States., Hardie R; Department of Anesthesiology and Critical Care, Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States., Janke E; Center for Consciousness Science, Department of Anesthesiology, University of Michigan Medical School, Ann Arbor, United States., Golmirzaie G; Center for Consciousness Science, Department of Anesthesiology, University of Michigan Medical School, Ann Arbor, United States., Picton P; Center for Consciousness Science, Department of Anesthesiology, University of Michigan Medical School, Ann Arbor, United States., McKinstry-Wu AR; Department of Anesthesiology and Critical Care, Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States., Avidan MS; Department of Anesthesiology, Washington University School of Medicine, St. Louis, United States., Kelz MB; Department of Anesthesiology and Critical Care, Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States.
Jazyk:	angličtina
Zdroj:	ELife [Elife] 2021 May 10; Vol. 10. Date of Electronic Publication: 2021 May 10.
DOI:	10.7554/eLife.59525
Abstrakt:	Understanding how the brain recovers from unconsciousness can inform neurobiological theories of consciousness and guide clinical investigation. To address this question, we conducted a multicenter study of 60 healthy humans, half of whom received general anesthesia for 3 hr and half of whom served as awake controls. We administered a battery of neurocognitive tests and recorded electroencephalography to assess cortical dynamics. We hypothesized that recovery of consciousness and cognition is an extended process, with differential recovery of cognitive functions that would commence with return of responsiveness and end with return of executive function, mediated by prefrontal cortex. We found that, just prior to the recovery of consciousness, frontal-parietal dynamics returned to baseline. Consistent with our hypothesis, cognitive reconstitution after anesthesia evolved over time. Contrary to our hypothesis, executive function returned first. Early engagement of prefrontal cortex in recovery of consciousness and cognition is consistent with global neuronal workspace theory. Competing Interests: GM, BP, MB, DL, WW, SB, NL, KM, MM, VT, GV, EO, RH, MS, HM, RH, EJ, GG, PP, AM, MA, MK No competing interests declared (© 2021, Mashour et al.)
Databáze:	MEDLINE
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