Bioactive Compounds Effective Against Type 2 Diabetes Mellitus: A Systematic Review.

Autor:	Egbuna C; World Bank Africa Centre of Excellence in Public Health and Toxicological Research (PUTOR), University of Port-Harcourt, Rivers State, Nigeria., Awuchi CG; School of Natural and Applied Sciences, Kampala International University, Kampala, Uganda., Kushwaha G; Department of Biotechnology, Indian Institute of Technology, Roorkee-247667, India., Rudrapal M; Sandip Institute of Pharmaceutical Sciences, Sandip Foundation, Nashik Maharashtra, India., Patrick-Iwuanyanwu KC; World Bank Africa Centre of Excellence in Public Health and Toxicological Research (PUTOR), University of Port-Harcourt, Rivers State, Nigeria., Singh O; Department of Chemical Engineering, Indian Institute of Technology Madras, Chennai-600036, India., Odoh UE; Department of Pharmacognosy and Environmental Medicines, Faculty of Pharmaceutical Sciences, University of Nigeria, Nsukka, Nigeria., Khan J; Department of Medical Laboratory Sciences, College of Applied Medical Sciences, Majmaah University, Majmaah, 11952, Saudi Arabia., Jeevanandam J; CQM - Centro de Química da Madeira, Universidade da Madeira, Campus da Penteada, 9020-105 Funchal, Portugal., Kumarasamy S; PG and Research Centre in Biotechnology, MGR College, Hosur, Krishnagiri -635 130, Tamil Nadu, India., Chukwube VO; Department of Pharmacognosy and Environmental Medicines, Faculty of Pharmaceutical Sciences, University of Nigeria, Nsukka, Nigeria., Narayanan M; PG and Research Centre in Biotechnology, MGR College, Hosur, Krishnagiri -635 130, Tamil Nadu, India., Palai S; Department of Veterinary Pharmacology & Toxicology, College of Veterinary Science and Animal Husbandry, OUAT, Bhubaneswar-751003, Odisha, India., Găman MA; Faculty of Medicine, 'Carol Davila' University of Medicine and Pharmacy, Bucharest, Romania & Department of Hematology, Center of Hematology and Bone Marrow Transplantation, Fundeni Clinical Institute, Bucharest, Romania., Uche CZ; Department of Medical Biochemistry and Molecular Biology, Faculty of Basic Medical Sciences, University of Nigeria, Enugu Campus, Nigeria., Ogaji DS; Department of Preventive and Social Medicine, University of Port Harcourt, Rivers State, Nigeria., Ezeofor NJ; Department of Food Technology, School of Applied Science and Technology, Federal Polytechnic, Oko, Anambra State, Nigeria., Mtewa AG; Chemistry Section, Malawi Institute of Technology, Malawi University of Science and Technology, P.O. Box 5196, Limbe, Malawi., Patrick-Iwuanyanwu CC; Department of Internal Medicine, Endocrinology, Diabetes and Metabolism Unit, University of Port Harcourt Teaching Hospital, Rivers State, Nigeria., Kesh SS; Department of Veterinary Clinical Complex, Faculty of Veterinary and Animal Sciences, West Bengal University of Animal and Fishery Sciences, Kolkata-700037, West Bengal, India., Shivamallu C; Department of Biotechnology and Bioinformatics, School of Life Sciences, JSS Academy of Higher Education & Research, Mysuru, Karnataka-570 015, India., Saravanan K; PG and Research Department of Zoology, Nehru Memorial College (Autonomous), Puthanampatti - 621 007 Affiliated to Bharathidasan University, Tiruchirappalli, Tamil Nadu, India., Tijjani H; Department of Biochemistry, Natural Product Research Laboratory, Bauchi State University, Gadau, Nigeria., Akram M; Department of Eastern Medicines, Government College University, Faisalabad, Pakistan., Ifemeje JC; Department of Biochemistry, Faculty of Natural Sciences, Chukwuemeka Odumegwu Ojukwu University, Uli Campus, Anambra State -431124, Nigeria., Olisah MC; Department of Medical Biochemistry, Faculty of Basic Medicine, Chukwuemeka Odumegwu Ojukwu University, Anambra State -431124, Nigeria., Chikwendu CJ; Department of Biochemistry, Faculty of Natural Sciences, Chukwuemeka Odumegwu Ojukwu University, Uli Campus, Anambra State -431124, Nigeria.
Jazyk:	angličtina
Zdroj:	Current topics in medicinal chemistry [Curr Top Med Chem] 2021; Vol. 21 (12), pp. 1067-1095.
DOI:	10.2174/1568026621666210509161059
Abstrakt:	Background: Type 2 diabetes (adult onset diabetes) is the most common type of diabetes, accounting for around 90% of all diabetes cases with insulin resistance and insulin secretion defect. The key goal of anti-diabetic therapy is to increase the development of insulin, immunity and/or decrease the amount of blood glucose. While many synthetic compounds have been produced as antidiabetic agents, due to their side effects and limited effectiveness, their usefulness has been hindered. Methods: This systematic review investigated the bioactive compounds reported to possess activities against type 2 diabetes. Three (3) databases, PubMed, ScienceDirect and Google Scholar were searched for research articles published between January 2010 and October 2020. A total of 6464 articles were identified out of which 84 articles were identified to be elligible for the study. Result and Discussion: From the data extracted, it was found that quercetin, Kaempferol, Rosmarinic acid, Cyanidin, Rutin, Catechin, Luteolin and Ellagic acid were the most cited bioactive compounds which all falls within the class of polyphenolic compounds. The major sources of these bioactive compounds includes citrus fruits, grapes, onions, berries, cherries, broccoli, honey, apples, green tea, Ginkgo biloba, St. John's wort, green beans, cucumber, spinach, tea, Rosmarinus officinalis, Aloe vera, Moringa oleifera, tomatoes, potatoes, oregano, lemon balm, thyme, peppermint, Ocimum basilicum, red cabbage, pears, olive oil and walnut. (Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.)
Databáze:	MEDLINE
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