| Autor: |
Martín-Márquez BT; Department of Molecular Biology and Genomics. Instituto de Investigación en Reumatología y del Sistema Músculo Esquelético (IIRSME). Centro Universitario de Ciencias de la Salud. Universidad de Guadalajara., Sandoval-Garcia F; Department of Molecular Biology and Genomics. Instituto de Investigación en Reumatología y del Sistema Músculo Esquelético (IIRSME). Centro Universitario de Ciencias de la Salud. Universidad de Guadalajara., Vazquez-Del Mercado M; Department of Molecular Biology and Genomics. Instituto de Investigación en Reumatología y del Sistema Músculo Esquelético (IIRSME). Centro Universitario de Ciencias de la Salud. Universidad de Guadalajara., Martínez-García EA; Department of Molecular Biology and Genomics. Instituto de Investigación en Reumatología y del Sistema Músculo Esquelético (IIRSME). Centro Universitario de Ciencias de la Salud. Universidad de Guadalajara., Corona-Meraz FI; CA-701, Ageing, Immuno-Metabolism, and Oxidative Stress. Department of Public Health. Universidad de Guadalajara., Fletes-Rayas AL; Department of Applied Integral Clinical Nursing. Centro Universitario de Ciencias de la Salud. Universidad de Guadalajara. Guadalajara., Zavaleta-Muñiz SA; Facultad de Ciencias de la Salud. Universidad Juárez del Estado de Durango. |
| Abstrakt: |
Introduction: Background: type-2 diabetes mellitus (T2DM) is a chronic metabolic disorder characterized by hyperglycemia, insulin resistance (IR), and abnormal fatty acid metabolism in which the CD36 receptor has been implicated in glucose and lipid dysregulation. Objective: to evaluate the contribution of polymorphism CD36 rs3211938 to metabolic profile in T2DM Mexican mestizos from western Mexico. Methods: we included 115 individuals classified as non-T2DM (NT2DM) adults and T2DM patients. Polymorphism CD36 rs3211938 was assessed by PCR-RFLP. Anthropometric and metabolic markers were measured by routine methods, and insulin and oxidized LDL (ox-LDL) were measured by ELISA. Results: the distribution of genotypes between NT2DM and T2DM patients was different (p < 0.001), as was the allele frequency (p = 0.002). NT2DM TG carriers showed the lowest levels of basal insulin and HOMA-IR index in comparison with TT carriers (p < 0.05 and p < 0.05, respectively). In the T2DM group TG carriers showed high BMI, WHR, and weight values (p = 0.001; p ≤ 0.05 and p < 0.05, respectively), and the highest levels of basal glucose, HDL-cholesterol, ox-LDL, and HOMA-IR (p < 0.001; p < 0.001; p < 0.001, and p = 0.001, respectively) in comparison with diabetic TT carriers. Conclusion: the CD36 rs3211938 TG genotype is associated with high levels of glucose, ox-LDL, HDL-cholesterol, and IR, and with increased BMI in Mexican mestizo T2DM patients from western Mexico. |
