Effect of exercise-conditioned human serum on the viability of cancer cell cultures: A systematic review and meta-analysis.

Autor:	Soares CM; University of Coimbra - Research Unit for Sport and Physical Activity (CIDAF, UID/PTD/04213/2019), Faculty of Sport Sciences and Physical Education, 3040-248 Coimbra, Portugal; carlos.soares@student.fcdef.uc.pt (C.M.S.); ateixeira@fcdef.uc.pt (A.M.T.); hugo.sarmento@uc.pt (H.S.); geral.fernandasilva@gmail.com (F.M.S.); marciocascante@gmail.com (M.C.R.); prnobre@fcdef.uc.pt (P.R.N.); miguelfachada@fcdef.uc.pt (M.A.F.); jpferreira@fcdef.uc.pt (J.P.L.).; Higher Institute of Educational Sciences of the Douro, 4560-708 Penafiel, Portugal., Teixeira AM; University of Coimbra - Research Unit for Sport and Physical Activity (CIDAF, UID/PTD/04213/2019), Faculty of Sport Sciences and Physical Education, 3040-248 Coimbra, Portugal; carlos.soares@student.fcdef.uc.pt (C.M.S.); ateixeira@fcdef.uc.pt (A.M.T.); hugo.sarmento@uc.pt (H.S.); geral.fernandasilva@gmail.com (F.M.S.); marciocascante@gmail.com (M.C.R.); prnobre@fcdef.uc.pt (P.R.N.); miguelfachada@fcdef.uc.pt (M.A.F.); jpferreira@fcdef.uc.pt (J.P.L.)., Sarmento H; University of Coimbra - Research Unit for Sport and Physical Activity (CIDAF, UID/PTD/04213/2019), Faculty of Sport Sciences and Physical Education, 3040-248 Coimbra, Portugal; carlos.soares@student.fcdef.uc.pt (C.M.S.); ateixeira@fcdef.uc.pt (A.M.T.); hugo.sarmento@uc.pt (H.S.); geral.fernandasilva@gmail.com (F.M.S.); marciocascante@gmail.com (M.C.R.); prnobre@fcdef.uc.pt (P.R.N.); miguelfachada@fcdef.uc.pt (M.A.F.); jpferreira@fcdef.uc.pt (J.P.L.)., Silva FM; University of Coimbra - Research Unit for Sport and Physical Activity (CIDAF, UID/PTD/04213/2019), Faculty of Sport Sciences and Physical Education, 3040-248 Coimbra, Portugal; carlos.soares@student.fcdef.uc.pt (C.M.S.); ateixeira@fcdef.uc.pt (A.M.T.); hugo.sarmento@uc.pt (H.S.); geral.fernandasilva@gmail.com (F.M.S.); marciocascante@gmail.com (M.C.R.); prnobre@fcdef.uc.pt (P.R.N.); miguelfachada@fcdef.uc.pt (M.A.F.); jpferreira@fcdef.uc.pt (J.P.L.)., Rusenhack MC; University of Coimbra - Research Unit for Sport and Physical Activity (CIDAF, UID/PTD/04213/2019), Faculty of Sport Sciences and Physical Education, 3040-248 Coimbra, Portugal; carlos.soares@student.fcdef.uc.pt (C.M.S.); ateixeira@fcdef.uc.pt (A.M.T.); hugo.sarmento@uc.pt (H.S.); geral.fernandasilva@gmail.com (F.M.S.); marciocascante@gmail.com (M.C.R.); prnobre@fcdef.uc.pt (P.R.N.); miguelfachada@fcdef.uc.pt (M.A.F.); jpferreira@fcdef.uc.pt (J.P.L.)., Furmann M; Universidade Estadual do Centro Oeste, 84505-677 Irati Paraná, Brasil; meiry.furmann2@gmail.com (M.F.)., Nobre PR; University of Coimbra - Research Unit for Sport and Physical Activity (CIDAF, UID/PTD/04213/2019), Faculty of Sport Sciences and Physical Education, 3040-248 Coimbra, Portugal; carlos.soares@student.fcdef.uc.pt (C.M.S.); ateixeira@fcdef.uc.pt (A.M.T.); hugo.sarmento@uc.pt (H.S.); geral.fernandasilva@gmail.com (F.M.S.); marciocascante@gmail.com (M.C.R.); prnobre@fcdef.uc.pt (P.R.N.); miguelfachada@fcdef.uc.pt (M.A.F.); jpferreira@fcdef.uc.pt (J.P.L.)., Fachada MA; University of Coimbra - Research Unit for Sport and Physical Activity (CIDAF, UID/PTD/04213/2019), Faculty of Sport Sciences and Physical Education, 3040-248 Coimbra, Portugal; carlos.soares@student.fcdef.uc.pt (C.M.S.); ateixeira@fcdef.uc.pt (A.M.T.); hugo.sarmento@uc.pt (H.S.); geral.fernandasilva@gmail.com (F.M.S.); marciocascante@gmail.com (M.C.R.); prnobre@fcdef.uc.pt (P.R.N.); miguelfachada@fcdef.uc.pt (M.A.F.); jpferreira@fcdef.uc.pt (J.P.L.)., Urbano AM; Molecular Physical Chemistry R & D Unit, Center of Investigation in Environment, Genetics and Oncobiology (CIMAGO), Department of Life Sciences, University of Coimbra, 3000-456 Coimbra, Portugal; amurbano@ci.uc.pt (A.M.U.)., Ferreira JP; University of Coimbra - Research Unit for Sport and Physical Activity (CIDAF, UID/PTD/04213/2019), Faculty of Sport Sciences and Physical Education, 3040-248 Coimbra, Portugal; carlos.soares@student.fcdef.uc.pt (C.M.S.); ateixeira@fcdef.uc.pt (A.M.T.); hugo.sarmento@uc.pt (H.S.); geral.fernandasilva@gmail.com (F.M.S.); marciocascante@gmail.com (M.C.R.); prnobre@fcdef.uc.pt (P.R.N.); miguelfachada@fcdef.uc.pt (M.A.F.); jpferreira@fcdef.uc.pt (J.P.L.).
Jazyk:	angličtina
Zdroj:	Exercise immunology review [Exerc Immunol Rev] 2021; Vol. 27, pp. 24-41.
Abstrakt:	Numerous epidemiological studies have shown the existence of a relationship between exercise and reduced risk of different types of cancer. In vitro studies have identified a direct effect of exercise-conditioned human serum on cancer cell lines of the lung, breast, prostate, and colon. The aim of this systematic review with meta-analysis (SRM) was to estimate the magnitude of the effect that exercise-conditioned human serum produced on the viability of cancer cell cultures. The design followed the PRISMA guidelines and the TREND statement to assess the quality of information (QoI) in each study. Nine in vitro studies were included in the SRM, involving a total of nine cancer cell lines and serum from 244 individuals from different countries, including namely healthy sedentary individuals, at risk of prostate cancer individuals and cancer patients, with ages ranging from 18 to 73 years. The impact of exerciseconditioned human serum on the viability of cancer cell cultures was analysed by a variety of assays, using pre-exercise human serum for comparison purposes. Globally, cultures of cancer cell lines exposed to human serum conditioned by exercise of various intensities exhibited a reduced viability, when compared with control cultures, with an overall effect size of -1.126 (95% CI; -1.300 to -0.952; p < 0.001). When the analysis only included human serum conditioned by high intensity exercise, the effect became more pronounced (ES -1.350; -1.522 to -1.179 (95% CI); p < 0.001). These results are in line with the hypothesis that changes in human serum induced by exercise might play a role in the beneficial effects of physical activity in cancer prevention and management and that these effects depend on exercise intensity. (Copyright © 2021 International Society of Exercise and Immunology. All rights reserved.)
Databáze:	MEDLINE
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