Predicting incident dementia and mild cognitive impairment in older women with nonparametric analysis of circadian activity rhythms in the Study of Osteoporotic Fractures.

Autor:	Posner AB; Research Institute, California Pacific Medical Center, San Francisco, CA, USA.; Division of Epidemiology & Biostatistics, School of Public Health, University of California, Berkeley, Berkeley, CA, USA., Tranah GJ; Research Institute, California Pacific Medical Center, San Francisco, CA, USA., Blackwell T; Research Institute, California Pacific Medical Center, San Francisco, CA, USA., Yaffe K; San Francisco VA Medical Center, San Francisco, CA, USA.; Department of Psychiatry and Behavioral Sciences, University of California, San Francisco, San Francisco, CA, USA.; Department of Neurology, University of California, San Francisco, San Francisco, CA, USA.; Department of Epidemiology & Biostatistics, University of California, San Francisco, San Francisco, CA, USA., Ancoli-Israel S; Department of Psychiatry, University of California, San Diego, La Jolla, CA, USA., Redline S; Departments of Medicine and Neurology, Brigham and Women's Hospital, and Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA., Leng Y; Department of Psychiatry and Behavioral Sciences, University of California, San Francisco, San Francisco, CA, USA., Zeitzer JM; Department of Psychiatry and Behavioral Sciences, Stanford University, Palo Alto, CA, USA.; Mental Illness Research, Education, and Clinical Center, VA Palo Alto Health Care System, Palo Alto, CA, USA.; Stanford Center for Sleep Sciences and Medicine, Stanford University, Palo Alto, CA, USA., Chen DM; Research Institute, California Pacific Medical Center, San Francisco, CA, USA.; Division of Epidemiology & Biostatistics, School of Public Health, University of California, Berkeley, Berkeley, CA, USA., Webber KR; Research Institute, California Pacific Medical Center, San Francisco, CA, USA.; Division of Epidemiology & Biostatistics, School of Public Health, University of California, Berkeley, Berkeley, CA, USA., Stone KL; Research Institute, California Pacific Medical Center, San Francisco, CA, USA.
Jazyk:	angličtina
Zdroj:	Sleep [Sleep] 2021 Oct 11; Vol. 44 (10).
DOI:	10.1093/sleep/zsab119
Abstrakt:	Study Objectives: Disrupted daily rhythms are associated with mild cognitive impairment (MCI) and dementia. The specific nature of how rhythms and cognition are related, however, is unknown. We hypothesized characteristics from a nonparametric estimate of circadian rest-activity rhythm patterns would be associated to the development of MCI or dementia. Methods: Wrist actigraphy from 1232 cognitively healthy, community-dwelling women (mean age 82.6 years) from the Study of Osteoporotic Fractures was used to estimate rest-activity patterns, including intradaily variability (IV), interdaily stability (IS), most active 10-hour period (M10), least active 5-hour period (L5), and relative amplitude (RA). Logistic regression examined associations of these predictors with 5-year incidence of MCI or dementia. Models were adjusted for potential confounders. Results: Women with earlier sleep/wake times had higher risk of dementia, but not MCI, (early vs. average L5 midpoint: OR, 1.66; 95% CI, 1.08-2.55) as did women with smaller day/night activity differentials (low vs. high RA: OR, 1.96; 95% CI, 1.14-3.35). IV, IS, and M10 were not associated with MCI or dementia. Conclusion: The timing and difference in day/night amplitude, but not variability of activity, may be useful as predictors of dementia. (© Sleep Research Society 2021. Published by Oxford University Press on behalf of the Sleep Research Society. All rights reserved. For permissions, please email: journals.permissions@oup.com.)
Databáze:	MEDLINE
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