Force balancing ACT-IN the tumor microenvironment: Cytoskeletal modifications in cancer and stromal cells to promote malignancy.

Autor:	Dawson MR; Department of Molecular Pharmacology, Physiology, and Biotechnology, Brown University, Providence, RI, United States; Department of Molecular Biology, Cell Biology and Biochemistry, Brown University, Providence, RI, United States; Brown University, Center for Biomedical Engineering, Providence, RI, United States. Electronic address: michelle_dawson@brown.edu., Xuan B; Department of Molecular Pharmacology, Physiology, and Biotechnology, Brown University, Providence, RI, United States., Hsu J; Department of Molecular Pharmacology, Physiology, and Biotechnology, Brown University, Providence, RI, United States., Ghosh D; Department of Molecular Pharmacology, Physiology, and Biotechnology, Brown University, Providence, RI, United States.
Jazyk:	angličtina
Zdroj:	International review of cell and molecular biology [Int Rev Cell Mol Biol] 2021; Vol. 360, pp. 1-31. Date of Electronic Publication: 2020 Oct 27.
DOI:	10.1016/bs.ircmb.2020.09.005
Abstrakt:	The tumor microenvironment is a complex milieu that dictates the growth, invasion, and metastasis of cancer cells. Both cancer and stromal cells in the tumor tissue encounter and adapt to a variety of extracellular factors, and subsequently contribute and drive the progression of the disease to more advanced stages. As the disease progresses, a small population of cancer cells becomes more invasive through a complex process known as epithelial-mesenchymal transition, and nearby stromal cells assume a carcinoma associated fibroblast phenotype characterized by enhanced migration, cell contractility, and matrix secretion with the ability to reorganize extracellular matrices. As cells transition into more malignant phenotypes their biophysical properties, controlled by the organization of cytoskeletal proteins, are altered. Actin and its associated proteins are essential modulators and facilitators of these changes. As the cells respond to the cues in the microenvironment, actin driven mechanical forces inside and outside the cells also evolve. Recent advances in biophysical techniques have enabled us to probe these actin driven changes in cancer and stromal cells and demarcate their role in driving changes in the microenvironment. Understanding the underlying biophysical mechanisms that drive cancer progression could provide critical insight on novel therapeutic approaches in the fight against cancer. (Copyright © 2021 Elsevier Inc. All rights reserved.)
Databáze:	MEDLINE
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