Isoflavanquinones from Abrus precatorius roots with their antiproliferative and anti-inflammatory effects.

Autor: Okoro EE; Biochemistry Department, Babcock University Ilishan-Remo, Ikeja, PMB 21244, Nigeria; Dr. Panjwani Center for Molecular Medicine and Drug Research (PCMD), International Center for Chemical and Biological Sciences, University of Karachi, Karachi, 75270, Pakistan; HEJ Research Institute of Chemistry, University of Karachi, Karachi, 75270, Pakistan; Biology Department, Adventist University of West Africa, Monrovia, Liberia. Electronic address: okoroemeka2003@gmail.com., Maharjan R; HEJ Research Institute of Chemistry, University of Karachi, Karachi, 75270, Pakistan., Jabeen A; Dr. Panjwani Center for Molecular Medicine and Drug Research (PCMD), International Center for Chemical and Biological Sciences, University of Karachi, Karachi, 75270, Pakistan., Ahmad MS; Dr. Panjwani Center for Molecular Medicine and Drug Research (PCMD), International Center for Chemical and Biological Sciences, University of Karachi, Karachi, 75270, Pakistan; HEJ Research Institute of Chemistry, University of Karachi, Karachi, 75270, Pakistan., Azhar M; Dr. Panjwani Center for Molecular Medicine and Drug Research (PCMD), International Center for Chemical and Biological Sciences, University of Karachi, Karachi, 75270, Pakistan., Shehla N; HEJ Research Institute of Chemistry, University of Karachi, Karachi, 75270, Pakistan., Zaman W; Dr. Panjwani Center for Molecular Medicine and Drug Research (PCMD), International Center for Chemical and Biological Sciences, University of Karachi, Karachi, 75270, Pakistan., Shams S; Dr. Panjwani Center for Molecular Medicine and Drug Research (PCMD), International Center for Chemical and Biological Sciences, University of Karachi, Karachi, 75270, Pakistan., Osoniyi OR; Department of Biochemistry and Molecular Biology, Obafemi Awolowo University, Ile Ife, Nigeria., Onajobi FD; Biochemistry Department, Babcock University Ilishan-Remo, Ikeja, PMB 21244, Nigeria., Choudhary MI; Dr. Panjwani Center for Molecular Medicine and Drug Research (PCMD), International Center for Chemical and Biological Sciences, University of Karachi, Karachi, 75270, Pakistan; HEJ Research Institute of Chemistry, University of Karachi, Karachi, 75270, Pakistan.
Jazyk: angličtina
Zdroj: Phytochemistry [Phytochemistry] 2021 Jul; Vol. 187, pp. 112743. Date of Electronic Publication: 2021 May 04.
DOI: 10.1016/j.phytochem.2021.112743
Abstrakt: Phytochemical studies on the root of Abrus precatorius Linn. (Fabaceae), leads towards the identification of four undescribed (abruquinones M, N, O, and P), and seven known abruquinones, (abruquinones A, E, B, F, I, D, and G). Spectroscopic analyses (1D, and 2D NMR, HRESI-MS) were used in elucidating structures of the all compounds. Evaluation of anticancer activities of the isolated isoflavanquinones revealed that abruquinones M, and N showed cytotoxicity against oral CAL-27 (IC 50 values 6.48 and 5.26 μM, respectively), and colon (Caco- 2 ) cell lines (IC 50 values 15.79 and 10.33 μM, respectively). Abruquinone M also inhibited the growth of lung cancer cells (NCI-H460) with IC 50 of 31.33 μM. The isolated isoflavanquiones also showed potent anti-inflammatory potential through phagocyte oxidative burst and pro-inflammatory cytokine TNF-α inhibition in vitro. These findings suggest isoflavanquinones from A. precatorius roots as candidates for further research in cancer treatment.
(Copyright © 2021 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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