Prediction of reproductive function recovery after microsurgical varicocelectomy in men from infertile couples: Clinical and laboratory predictors.

Autor: Shomarufov AB; Department of Urology and Andrology, Faculty of Fundamental Medicine, Lomonosov Moscow State University, Moscow, Russia.; Department of Urology (clinical center - Republican Specialized Scientific-Practical Medical Center of Urology), Tashkent Medical Academy, Tashkent, Uzbekistan., Bozhedomov VA; Department of Urology and Andrology, Faculty of Fundamental Medicine, Lomonosov Moscow State University, Moscow, Russia., Akilov FA; Department of Urology (clinical center - Republican Specialized Scientific-Practical Medical Center of Urology), Tashkent Medical Academy, Tashkent, Uzbekistan., Mukhtarov ST; Department of Urology (clinical center - Republican Specialized Scientific-Practical Medical Center of Urology), Tashkent Medical Academy, Tashkent, Uzbekistan., Giyasov SI; Department of Urology (clinical center - Republican Specialized Scientific-Practical Medical Center of Urology), Tashkent Medical Academy, Tashkent, Uzbekistan., Abbosov SA; Department of Urology and Andrology, Faculty of Fundamental Medicine, Lomonosov Moscow State University, Moscow, Russia.; Department of Urology (clinical center - Republican Specialized Scientific-Practical Medical Center of Urology), Tashkent Medical Academy, Tashkent, Uzbekistan., Kamalov AA; Department of Urology and Andrology, Faculty of Fundamental Medicine, Lomonosov Moscow State University, Moscow, Russia.
Jazyk: angličtina
Zdroj: Andrologia [Andrologia] 2021 Sep; Vol. 53 (8), pp. e14101. Date of Electronic Publication: 2021 May 07.
DOI: 10.1111/and.14101
Abstrakt: The objective was to reveal predictors for fertility recovery after varicocelectomy in subfertile men. This retrospective study recruited 93 men with clinical varicocele and pathozoospermia who underwent microsurgical varicocelectomy. Stepwise discriminant analysis was performed to identify predictors of spontaneous pregnancy (SP) after surgery. 'Clinically significant improvement' (CSI) following varicocelectomy was defined as an increase in total progressively motile sperm count (TPMSC) by at least 12.5 million (calculated from WHO-2010 reference values). 52% of patients showed CSI, and 28% reported SP after surgery. Patients who reported SP (group II), compared to that remained infertile (group I), were younger (27.3 ± 2.9 versus 30.2 ± 4.2 years; p < .01), had less infertility period (24.1 ± 14.0 versus 44.4 ± 32.9 months; p < .05) and had initially higher TPMSC (median (25% -75%) = 34 (11-67) versus 9.5 (0-33) mln; p < .05). The stepwise discriminant analysis showed that male age (coefficient value = -0.157), total sperm motility (0.024) and postoperative increase in TPMSC (0.010) were the significant predictors of SP. The predictive ability, sensitivity and specificity of the discriminant function were 84%, 87%, 76% respectively. This algorithm can be recommended after varicocelectomy in decision-making on natural conception or the ART protocols usage.
(© 2021 Wiley-VCH GmbH.)
Databáze: MEDLINE
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