Sunlight exposure in infancy decreases risk of sporadic retinoblastoma, extent of intraocular disease.

Autor: Orjuela-Grimm M; Mailman School of Public Health, Department of Epidemiology, Columbia University Medical Center, New York, New York, USA.; Department of Pediatrics (Division of Pediatric Hematology, Oncology, and Stem Cell Transplantation), Columbia University Medical Center, New York, New York, USA., Carreño SB; Mailman School of Public Health, Department of Epidemiology, Columbia University Medical Center, New York, New York, USA., Liu X; Mailman School of Public Health, Department of Biostatistics, Columbia University Medical Center, New York, New York, USA., Ruiz A; Mailman School of Public Health, Department of Epidemiology, Columbia University Medical Center, New York, New York, USA., Medina P; Mailman School of Public Health, Department of Epidemiology, Columbia University Medical Center, New York, New York, USA., Ramirez Ortiz MA; Department of Ophthalmology, Hospital Infantil de Mexico, Federico Gomez, Mexico City, Mexico., Rendon JR; Centro Medico Nacional Siglo XXI, Instituto Mexicano de Seguro Social, Hospital de Pediatria, Mexico City, Mexico., Molina NCL; Department of Ophthalmology, Hospital Infantil de Mexico, Federico Gomez, Mexico City, Mexico., Pinilla H; Mailman School of Public Health, Department of Epidemiology, Columbia University Medical Center, New York, New York, USA., Hinojosa D; Mailman School of Public Health, Department of Epidemiology, Columbia University Medical Center, New York, New York, USA., Rodriguez L; Mailman School of Public Health, Department of Epidemiology, Columbia University Medical Center, New York, New York, USA., Connor AO; Mailman School of Public Health, Department of Environmental Health Science, Columbia University Medical Center, New York, New York, USA., Rodriguez FM; Centro de Investigacion de Nutricion y Salud, Instituto Nacional de Salud Publica, Cuernavaca, Mexico., Castañeda MVP; Centro Medico Nacional Siglo XXI, Instituto Mexicano de Seguro Social, Hospital de Pediatria, Mexico City, Mexico., Cabrera-Muñoz L; Department of Pathology, Hospital Infantil de Mexico, Federico Gomez, Mexico City, Mexico.
Jazyk: angličtina
Zdroj: Cancer reports (Hoboken, N.J.) [Cancer Rep (Hoboken)] 2021 Dec; Vol. 4 (6), pp. e1409. Date of Electronic Publication: 2021 May 07.
DOI: 10.1002/cnr2.1409
Abstrakt: Background: Prior ecologic studies suggest that UV exposure through sunlight to the retina might contribute to increased retinoblastoma incidence.
Aims: Our study objectives were (1) to examine the relationship between exposure to sunlight during postnatal retinal development (prior to diagnosis of sporadic disease) and the risk of retinoblastoma, and (2) to examine the relationship between sun exposure during postnatal retinal development, and the extent of disease among children with unilateral and bilateral retinoblastoma.
Methods and Results: We interviewed 511 mothers in the EpiRbMx case-control study about their child's exposure to sunlight during postnatal retinal cell division by examining three time periods prior to Rtb diagnosis coinciding with developmental stages in which outdoor activities vary. Weekly sun exposure was compared by age period, between unilateral (n = 259), bilateral (n = 120), and control (n = 132) children, accounting for two factors affecting UV exposure: residential elevation and reported use of coverings to shield eyes. For cases, association between sunlight exposure and clinical stage was examined by laterality at each age period. After adjusting for maternal education and elevation, sun exposure was lower in cases than controls in all three age periods especially during the first 6 months, and in children 12-23 months whose mothers did not cover their eyes when outdoors. In children diagnosed after 12 months of age, sun exposure during the second year of life (age 12-23 months) appeared inversely correlated (r = -0.25) with more advanced intraocular disease in bilateral Rtb children after adjusting for maternal education, residential elevation, and age of diagnosis (p < .09) consistent with effects of Vitamin D exposure on intraocular spread in earlier transgenic murine models of retinoblastoma, and suggesting potential chemopreventive strategies.
Conclusion: Sun exposure in early childhood is protective for retinoblastoma and may decrease degree of intraocular spread in children with bilateral Rtb.
(© 2021 The Authors. Cancer Reports published by Wiley Periodicals LLC.)
Databáze: MEDLINE
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