IDH-mutant brainstem gliomas in adolescent and young adult patients: Report of three cases and review of the literature.
Autor: | Chang EK; Division of Hematology, Oncology and Blood & Marrow Transplantation, Children's Center for Cancer and Blood Diseases, Children's Hospital Los Angeles, Los Angeles, CA, USA., Smith-Cohn MA; Department of Neurology, Johns Hopkins Hospital, Baltimore, MD, USA.; Neuro-Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA., Tamrazi B; Department of Radiology, Children's Hospital Los Angeles, Los Angeles, CA, USA., Ji J; Department of Pathology and Laboratory Medicine, Children's Hospital Los Angeles, Los Angeles, CA, USA., Krieger M; Division of Neurosurgery, Children's Hospital Los Angeles, Los Angeles, CA, USA., Holdhoff M; Department of Oncology, Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD, USA., Eberhart CG; Department of Pathology, Johns Hopkins Hospital, Baltimore, MD, USA., Margol AS; Division of Hematology, Oncology and Blood & Marrow Transplantation, Children's Center for Cancer and Blood Diseases, Children's Hospital Los Angeles, Los Angeles, CA, USA., Cotter JA; Department of Pathology and Laboratory Medicine, Children's Hospital Los Angeles, Los Angeles, CA, USA. |
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Jazyk: | angličtina |
Zdroj: | Brain pathology (Zurich, Switzerland) [Brain Pathol] 2021 Jul; Vol. 31 (4), pp. e12959. Date of Electronic Publication: 2021 May 07. |
DOI: | 10.1111/bpa.12959 |
Abstrakt: | Isocitrate dehydrogenase (IDH) mutations are rare in pediatric and adolescent gliomas. We recently identified three adolescent/young adult (AYA) patients with IDH-mutant low grade gliomas of the brainstem with several key clinicopathologic and molecular features in common. We discuss these three cases and review the current literature. (© 2021 The Authors. Brain Pathology published by John Wiley & Sons Ltd on behalf of International Society of Neuropathology.) |
Databáze: | MEDLINE |
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