Snail-Family Proteins: Role in Carcinogenesis and Prospects for Antitumor Therapy.
| Autor: | Yastrebova MA; Institute of Gene Biology, Russian Academy of Sciences, Moscow, 119334 Russia., Khamidullina AI; Institute of Gene Biology, Russian Academy of Sciences, Moscow, 119334 Russia., Tatarskiy VV; Institute of Gene Biology, Russian Academy of Sciences, Moscow, 119334 Russia.; Blokhin National Medical Research Center of Oncology, Moscow, 115478 Russia., Scherbakov AM; Blokhin National Medical Research Center of Oncology, Moscow, 115478 Russia. |
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| Jazyk: | angličtina |
| Zdroj: | Acta naturae [Acta Naturae] 2021 Jan-Mar; Vol. 13 (1), pp. 76-90. |
| DOI: | 10.32607/actanaturae.11062 |
| Abstrakt: | The review analyzes Snail family proteins, which are transcription factors involved in the regulation of the epithelial-mesenchymal transition (EMT) of tumor cells. We describe the structure of these proteins, their post-translational modification, and the mechanisms of Snail-dependent regulation of genes. The role of Snail proteins in carcinogenesis, invasion, and metastasis is analyzed. Furthermore, we focus on EMT signaling mechanisms involving Snail proteins. Next, we dissect Snail signaling in hypoxia, a condition that complicates anticancer treatment. Finally, we offer classes of chemical compounds capable of down-regulating the transcriptional activity of Snails. Given the important role of Snail proteins in cancer biology and the potential for pharmacological inhibition, Snail family proteins may be considered promising as therapeutic targets. (Copyright ® 2021 National Research University Higher School of Economics.) |
| Databáze: | MEDLINE |
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