Urinary prostaglandin E2 as a biomarker for recurrent UTI in postmenopausal women.

Autor: Ebrahimzadeh T; Department of Biological Sciences, University of Texas at Dallas, Richardson, TX, USA., Kuprasertkul A; Department of Urology, University of Texas Southwestern Medical Center, Dallas, TX, USA., Neugent ML; Department of Biological Sciences, University of Texas at Dallas, Richardson, TX, USA., Lutz KC; Depatment of Mathematics, University of Texas at Dallas, Richardson, TX, USA., Fuentes JL; Department of Urology, University of Texas Southwestern Medical Center, Dallas, TX, USA., Gadhvi J; Department of Biological Sciences, University of Texas at Dallas, Richardson, TX, USA., Khan F; Department of Biological Sciences, University of Texas at Dallas, Richardson, TX, USA., Zhang C; Depatment of Mathematics, University of Texas at Dallas, Richardson, TX, USA., Sharon BM; Department of Biological Sciences, University of Texas at Dallas, Richardson, TX, USA., Orth K; Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX, USA.; Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, TX, USA.; Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX, USA., Li Q; Depatment of Mathematics, University of Texas at Dallas, Richardson, TX, USA., Zimmern PE; Department of Urology, University of Texas Southwestern Medical Center, Dallas, TX, USA., De Nisco NJ; Department of Biological Sciences, University of Texas at Dallas, Richardson, TX, USA nicole.denisco@utdallas.edu.
Jazyk: angličtina
Zdroj: Life science alliance [Life Sci Alliance] 2021 May 06; Vol. 4 (7). Date of Electronic Publication: 2021 May 06 (Print Publication: 2021).
DOI: 10.26508/lsa.202000948
Abstrakt: Urinary tract infection (UTI) is one of the most common adult bacterial infections and exhibits high recurrence rates, especially in postmenopausal women. Studies in mouse models suggest that cyclooxygenase-2 (COX-2)-mediated inflammation sensitizes the bladder to recurrent UTI (rUTI). However, COX-2-mediated inflammation has not been robustly studied in human rUTI. We used human cohorts to assess urothelial COX-2 production and evaluate its product, PGE 2 , as a biomarker for rUTI in postmenopausal women. We found that the percentage of COX-2-positive cells was elevated in inflamed versus uninflamed bladder regions. We analyzed the performance of urinary PGE 2 as a biomarker for rUTI in a controlled cohort of 92 postmenopausal women and PGE 2 consistently outperformed all other tested clinical variables as a predictor of rUTI status. Furthermore, time-to-relapse analysis indicated that the risk of rUTI relapse was 3.6 times higher in women with above median urinary PGE 2 levels than with below median levels. Taken together, these data suggest that urinary PGE 2 may be a clinically useful diagnostic and prognostic biomarker for rUTI in postmenopausal women.
(© 2021 Ebrahimzadeh et al.)
Databáze: MEDLINE
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