The predictors of COVID-19 mortality in a nationwide cohort of Turkish patients.

Autor: Kokturk N; Department of Pulmonary Medicine, Faculty of Medicine, Gazi University, Ankara, Turkey. Electronic address: kokturk.nurdan@gmail.com., Babayigit C; Department of Pulmonary Medicine, Faculty of Medicine, Mustafa Kemal University, Hatay, Turkey. Electronic address: cbabayigit@gmail.com., Kul S; Department of Biostatistics, Faculty of Medicine, Gaziantep University, Gaziantep, Turkey. Electronic address: sevalkul@gantep.edu.tr., Duru Cetinkaya P; Department of Pulmonary Medicine, University of Health Sciences, Adana City Training and Research Hospital, Adana, Turkey. Electronic address: pelindurucetinkaya@hotmail.com., Atis Nayci S; Department of Pulmonary Medicine, Faculty of Medicine, Mersin University, Mersin, Turkey. Electronic address: atissibel@gmail.com., Argun Baris S; Department of Pulmonary Medicine, Faculty of Medicine, Kocaeli University, Kocaeli, Turkey. Electronic address: serapargun2002@yahoo.com., Karcioglu O; Department of Pulmonary Medicine, Halil Sıvgın Cubuk State Hospital, Ankara, Turkey. Electronic address: oguzkarcioglu@gmail.com., Aysert P; Department of Infectious Disease, Faculty of Medicine, Gazi University, Ankara, Turkey. Electronic address: pinar_aysert@yahoo.com., Irmak I; Department of Pulmonary Medicine, Faculty of Medicine, Hacettepe University, Ankara, Turkey. Electronic address: ilimirmak@hotmail.com., Akbas Yuksel A; Department of Pulmonary Medicine, Faculty of Medicine, Ufuk University, Ankara, Turkey. Electronic address: aycnakbas@hotmail.com., Sekibag Y; Department of Pulmonary Disease, Cerrahpasa Faculty of Medicine, Istanbul University-Cerrahpasa, Istanbul, Turkey. Electronic address: yoncahacioglu@gmail.com., Baydar Toprak O; Department of Pulmonary Medicine, Faculty of Medicine, Cukurova University, Adana, Turkey. Electronic address: oyabaydarr@yahoo.com.tr., Azak E; Department of Infectious Disease and Clinical Microbiology, Faculty of Medicine, Kocaeli University, Kocaeli Turkey. Electronic address: emelazak@mynet.com., Mulamahmutoglu S; Department of Pulmonary Disease, Cerrahpasa Faculty of Medicine, Istanbul University-Cerrahpasa, Istanbul, Turkey. Electronic address: saitmoglu@gmail.com., Cuhadaroglu C; Department of Pulmonary Medicine, Altunizade Acibadem Hospital, Istanbul, Turkey. Electronic address: caglar.cuhadaroglu@acibadem.com.tr., Demirel A; Department of Infectious Disease, Kadikoy Florence Nightingale Hospital, Istanbul, Turkey. Electronic address: demirelaslihan@yahoo.com., Kerget B; Department of Pulmonary Medicine, Faculty of Medicine, Ataturk University, Erzurum, Turkey. Electronic address: bjkerget1903@gmail.com., Baran Ketencioglu B; Department of Pulmonary Medicine, Faculty of Medicine, Erciyes University, Kayseri, Turkey. Electronic address: burcubaran@hotmail.com., Ozger HS; Department of Infectious Disease, Faculty of Medicine, Gazi University, Ankara, Turkey. Electronic address: sozger@yahoo.com., Ozkan G; Department of Pulmonary Medicine, Maslak Acibadem Hospital, Istanbul, Turkey; Operating Room Services Department, Nisantasi University, Vocational School, Istanbul, Turkey. Electronic address: gulcihanozkan@gmail.com., Ture Z; Department of Infectious Disease and Clinical Microbiology, Faculty of Medicine, Erciyes University, Kayseri, Turkey. Electronic address: dr.zeynepture@gmail.com., Ergan B; Department of Pulmonary Medicine, Faculty of Medicine, Dokuz Eylul University, Izmir, Turkey. Electronic address: begumergan@hotmail.com., Avkan Oguz V; Department of Infectious Disease and Clinical Microbiology, Faculty of Medicine, Dokuz Eylul University, Izmir, Turkey. Electronic address: vildan.oguz@gmail.com., Kilinc O; Department of Pulmonary Medicine, Faculty of Medicine, Dokuz Eylul University, Izmir, Turkey. Electronic address: oguz.kilinc@deu.edu.tr., Ercelik M; Department of Pulmonary Medicine, Faculty of Medicine, Duzce University, Duzce, Turkey. Electronic address: evrem-33@hotmail.com., Ulukavak Ciftci T; Department of Pulmonary Medicine, Faculty of Medicine, Gazi University, Ankara, Turkey. Electronic address: tansu.ciftci@gazi.edu.tr., Alici O; Department of Infectious Disease, Faculty of Medicine, Turkiye Gazetesi Private Hospital, Istanbul, Turkey. Electronic address: oalici@gmail.com., Nurlu Temel E; Department of Infectious Diseases and Clinical Microbiology, Faculty of Medicine, Suleyman Demirel University, Isparta, Turkey. Electronic address: dresratemel@gmail.com., Ataoglu O; Department of Pulmonary Medicine, Faculty of Medicine, Duzce University, Duzce, Turkey. Electronic address: dr.ozlemozturk@outlook.com., Aydin A; Department of Pulmonary Medicine, Kestel State Hospital, Bursa, Turkey. Electronic address: asenaarisoy@gmail.com., Cetiner Bahcetepe D; Department of Pulmonary Medicine, Kestel State Hospital, Bursa, Turkey. Electronic address: dilekbahcetepe@gmail.com., Gullu YT; Department of Pulmonary Medicine, Faculty of Medicine, On Dokuz Mayis University, Samsun, Turkey. Electronic address: tahagullu@gmail.com., Fakili F; Department of Pulmonary Medicine, Faculty of Medicine, Gaziantep University, Gaziantep, Turkey. Electronic address: fusunfakili@yahoo.com., Deveci F; Department of Pulmonary Medicine, Faculty of Medicine, Firat University, Elazig, Turkey. Electronic address: fgndeveci@yahoo.com., Kose N; Department of Pulmonary Medicine, Bilecik Training and Research Hospital, Bilecik, Turkey. Electronic address: neslihankose.nks@gmail.com., Tor MM; Department of Pulmonary Medicine, Faculty of Medicine, Zonguldak Bulent Ecevit University, Zonguldak, Turkey. Electronic address: meltemtor@gmail.com., Gunluoglu G; Department of Pulmonary Medicine, University of Health Science, Yedikule Chest Diseases and Chest Surgery Training and Research Hospital, Istanbul, Turkey. Electronic address: gunluoglu76@yahoo.com., Altin S; Department of Pulmonary Medicine, University of Health Science, Yedikule Chest Diseases and Chest Surgery Training and Research Hospital, Istanbul, Turkey. Electronic address: draltinsedat@gmail.com., Turgut T; Department of Pulmonary Medicine, Faculty of Medicine, Firat University, Elazig, Turkey. Electronic address: teyfikt@yahoo.com., Tuna T; Department of Pulmonary Medicine, Faculty of Medicine, On Dokuz Mayis University, Samsun, Turkey. Electronic address: tibeltuna@hotmail.com., Ozturk O; Department of Pulmonary Medicine, Faculty of Medicine, Suleyman Demirel University, Isparta, Turkey. Electronic address: dronderozturk@gmail.com., Dikensoy O; Department of Pulmonary Medicine, Faculty of Medicine, Taksim, Acibadem University, Istanbul, Turkey. Electronic address: dikensoy@yahoo.com., Yildiz Gulhan P; Department of Pulmonary Medicine, Faculty of Medicine, Duzce University, Duzce, Turkey. Electronic address: pinaryildiz691@hotmail.com., Basyigit I; Department of Pulmonary Medicine, Faculty of Medicine, Kocaeli University, Kocaeli, Turkey. Electronic address: ilknur.basyigit@gmail.com., Boyaci H; Department of Pulmonary Medicine, Faculty of Medicine, Kocaeli University, Kocaeli, Turkey. Electronic address: haboyaci@yahoo.com., Oguzulgen IK; Department of Pulmonary Medicine, Faculty of Medicine, Gazi University, Ankara, Turkey. Electronic address: ikoguzulgen@gmail.com., Borekci S; Department of Pulmonary Disease, Cerrahpasa Faculty of Medicine, Istanbul University-Cerrahpasa, Istanbul, Turkey. Electronic address: serminborekci@yahoo.com.tr., Gemicioglu B; Department of Pulmonary Disease, Cerrahpasa Faculty of Medicine, Istanbul University-Cerrahpasa, Istanbul, Turkey. Electronic address: bilung@gmail.com., Bayraktar F; Department of Internal Medicine, Faculty of Medicine, Dokuz Eylul University, Izmir, Turkey. Electronic address: firat.bayraktar@gmail.com., Elbek O; Department of Pulmonary Medicine, Kadikoy Florence Nightingale Hospital, Istanbul, Turkey. Electronic address: osmanelbek@yahoo.com., Hanta I; Department of Pulmonary Medicine, Faculty of Medicine, Cukurova University, Adana, Turkey. Electronic address: ismailhnt@gmail.com., Kuzu Okur H; Department of Pulmonary Medicine, Altunizade Acibadem Hospital, Istanbul, Turkey. Electronic address: hacerkuzu@hotmail.com., Sagcan G; Department of Pulmonary Medicine, Altunizade Acibadem Hospital, Istanbul, Turkey. Electronic address: gulserensagcan@yahoo.com., Uzun O; Department of Pulmonary Medicine, Faculty of Medicine, On Dokuz Mayis University, Samsun, Turkey. Electronic address: oguzuzun67@yahoo.com.tr., Akgun M; Department of Pulmonary Medicine, Faculty of Medicine, Ataturk University, Erzurum, Turkey. Electronic address: akgunm@gmail.com., Altinisik G; Department of Pulmonary Medicine, Faculty of Medicine, Pamukkale University, Denizli, Turkey. Electronic address: gaergur@gmail.com., Dursun B; Department of Pulmonary Medicine, Ankara Memorial Hospital, Ankara, Turkey. Electronic address: bernatoraks@gmail.com., Cakir Edis E; Department of Pulmonary Medicine, Faculty of Medicine, Trakya University, Edirne, Turkey. Electronic address: ebruckr@yahoo.com., Gulhan E; Department of Thoracic Surgery, Atatürk Chest Diseases and Thoracic Surgery Training and Research Hospital, Ankara, Turkey. Electronic address: egulhan@rocketmail.com., Oner Eyuboglu F; Department of Pulmonary Medicine, Baskent University, School of Medicine, Ankara, Turkey. Electronic address: fusuneyuboglu@gmail.com., Gultekin O; Department of Pulmonary Medicine, Faculty of Medicine, Celal Bayar University, Manisa, Turkey. Electronic address: o.gultekin@hotmail.com.tr., Havlucu Y; Department of Pulmonary Medicine, Faculty of Medicine, Celal Bayar University, Manisa, Turkey. Electronic address: dyhavlucu@yahoo.com., Ozkan M; Department of Pulmonary Medicine, Ankara Memorial Hospital, Ankara, Turkey. Electronic address: metin58@yahoo.com., Sakar Coskun A; Department of Pulmonary Medicine, Faculty of Medicine, Celal Bayar University, Manisa, Turkey. Electronic address: aysins@hotmail.com., Sayiner A; Department of Pulmonary Medicine, Faculty of Medicine, Ege University, Izmir, Turkey. Electronic address: abdullah.sayiner@ege.edu.tr., Kalyoncu AF; Department of Pulmonary Medicine, Faculty of Medicine, Hacettepe University, Ankara, Turkey. Electronic address: fuattoraks@gmail.com., Itil O; Department of Pulmonary Medicine, Faculty of Medicine, Dokuz Eylul University, Izmir, Turkey. Electronic address: oya.itil@deu.edu.tr., Bayram H; Department of Pulmonary Medicine, Koc University Research Center for Translational Medicine (KUTTAM), Koc University School of Medicine, Istanbul, Turkey. Electronic address: habayram@ku.edu.tr.
Jazyk: angličtina
Zdroj: Respiratory medicine [Respir Med] 2021 Jul; Vol. 183, pp. 106433. Date of Electronic Publication: 2021 Apr 28.
DOI: 10.1016/j.rmed.2021.106433
Abstrakt: The COVID-19-related death rate varies between countries and is affected by various risk factors. This multicenter registry study was designed to evaluate the mortality rate and the related risk factors in Turkey. We retrospectively evaluated 1500 adults with COVID-19 from 26 centers who were hospitalized between March 11 and July 31, 2020. In the study group, 1041 and 459 cases were diagnosed as definite and highly probable cases, respectively. There were 993 PCR-positive cases (66.2%). Among all cases, 1144 (76.3%) were diagnosed with non-severe pneumonia, whereas 212 (14.1%) had severe pneumonia. Death occurred in 67 patients, corresponding to a mortality rate of 4.5% (95% CI:3.5-5.6). The univariate analysis demonstrated that various factors, including male sex, age ≥65 years and the presence of dyspnea or confusion, malignity, chronic obstructive lung disease, interstitial lung disease, immunosuppressive conditions, severe pneumonia, multiorgan dysfunction, and sepsis, were positively associated with mortality. Favipiravir, hydroxychloroquine and azithromycin were not associated with survival. Following multivariate analysis, male sex, severe pneumonia, multiorgan dysfunction, malignancy, sepsis and interstitial lung diseases were found to be independent risk factors for mortality. Among the biomarkers, procalcitonin levels on the 3rd-5th days of admission showed the strongest associations with mortality (OR: 6.18; 1.6-23.93). This study demonstrated that the mortality rate in hospitalized patients in the early phase of the COVID-19 pandemic was a serious threat and that those patients with male sex, severe pneumonia, multiorgan dysfunction, malignancy, sepsis and interstitial lung diseases were at increased risk of mortality; therefore, such patients should be closely monitored.
(Copyright © 2021 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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