Antibacterial and modulatory activities of β-cyclodextrin complexed with (+)-β-citronellol against multidrug-resistant strains.

Autor: Silva Pereira RL; Department of Biological Chemistry, Regional University of Cariri, Crato, CE, Brazil., Campina FF; Department of Biological Chemistry, Regional University of Cariri, Crato, CE, Brazil., Costa MDS; Department of Biological Chemistry, Regional University of Cariri, Crato, CE, Brazil., Pereira da Cruz R; Department of Biological Chemistry, Regional University of Cariri, Crato, CE, Brazil., Sampaio de Freitas T; Department of Biological Chemistry, Regional University of Cariri, Crato, CE, Brazil., Lucas Dos Santos AT; Department of Biological Chemistry, Regional University of Cariri, Crato, CE, Brazil., Cruz BG; Department of Biological Chemistry, Regional University of Cariri, Crato, CE, Brazil., Maciel de Sena Júnior D; Department of Biological Chemistry, Regional University of Cariri, Crato, CE, Brazil., Campos Lima IK; Department of Biological Chemistry, Regional University of Cariri, Crato, CE, Brazil., Xavier MR; Department of Biological Chemistry, Regional University of Cariri, Crato, CE, Brazil., Rodrigues Teixeira AM; Department of Biological Chemistry, Regional University of Cariri, Crato, CE, Brazil; Department of Physics, Regional University of Cariri, Juazeiro do Norte, CE, Brazil., Alencar de Menezes IR; Department of Physics, Regional University of Cariri, Juazeiro do Norte, CE, Brazil., Quintans-Júnior LJ; Department of Physiology, Federal University of Sergipe, Aracaju-SE, Brazil., Araújo AAS; Department of Pharmacy, Federal University of Sergipe, Aracaju-SE, Brazil., Melo Coutinho HD; Department of Biological Chemistry, Regional University of Cariri, Crato, CE, Brazil. Electronic address: hdmcoutinho@gmail.com.
Jazyk: angličtina
Zdroj: Microbial pathogenesis [Microb Pathog] 2021 Jul; Vol. 156, pp. 104928. Date of Electronic Publication: 2021 May 03.
DOI: 10.1016/j.micpath.2021.104928
Abstrakt: The present study aimed to investigate the antibacterial and modulatory activities of (+)-β-citronellol (βCT), β-cyclodextrin (β-CD), and their complex βCT/β-CD and characterize them using infrared spectroscopy. Infrared spectra were recorded in the 750-4000 cm -1 region. The antibacterial effects of these compounds and their modulatory-antibiotic activities were determined using the minimum inhibitory concentration (MIC) test. Signatures of these pure compounds were detected in the infrared spectrum of the βCT/β-CD complex. The MIC of the βCT/β-CD complex against the tested strains was found to be 1024 μg/mL. The antagonistic and synergistic effects of these compounds were also observed using the modulation tests. βCT or β-CD alone did not exhibit any direct antibacterial activity. However, the βCT/β-CD complex in combination with gentamicin showed a synergistic effect against E. coli.
(Copyright © 2021 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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