Antimicrobial resistance and antibiotic consumption in a third level pediatric hospital in Mexico City.
| Autor: | Rosado-Rosado DA; Unidad de Medicina Familiar No. 13, Instituto Mexicano del Seguro Social, Cancún, Quintana Roo, México., Arias-Flores R; Hospital de Pediatría 'Doctor Silvestre Frenk Freund', Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Mexico City, Mexico., Vázquez-Rosales JG; Hospital de Pediatría 'Doctor Silvestre Frenk Freund', Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Mexico City, Mexico., Robles-Ramírez RJ; Hospital de Pediatría 'Doctor Silvestre Frenk Freund', Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Mexico City, Mexico., Del Campo-Ortega R; División de Evaluación de las Prestaciones Médicas, Instituto Mexicano del Seguro Social, Mexico City, Mexico., Ascencio-Montiel IJ; Coordinación de Vigilancia Epidemiológica, Instituto Mexicano del Seguro Social, Mexico City, Mexico. ivan-ascencio@hotmail.com. |
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| Jazyk: | angličtina |
| Zdroj: | Journal of infection in developing countries [J Infect Dev Ctries] 2021 Apr 30; Vol. 15 (4), pp. 573-578. Date of Electronic Publication: 2021 Apr 30. |
| DOI: | 10.3855/jidc.12646 |
| Abstrakt: | Introduction: The increasing resistance to antibiotics is a public health problem and an imminent therapeutic challenge in hospitals. In this report we aimed to analyze the relationship between antimicrobial resistance and antibiotic consumption in a third-level pediatric hospital. Methodology: A cross-sectional analysis was conducted using the information from the microbiology and pharmacy databases of the Pediatric Hospital "Doctor Silvestre Frenk Freund", during the period 2015-2018. Prevalence of antimicrobial resistance by microorganisms and dispensed grams of selected antibiotics were calculated annually. Antibiotic resistance trend over the time was evaluated using the Chi-square trends test and to assess the correlation between the dispensed grams of antibiotics with their antimicrobial resistance prevalence, we calculated the Pearson's coefficient (r). Results: A total of 4,327 isolated bacterial samples were analyzed (56.5% Gram-positive and 44.5% Gram-negative). Most frequently isolated microorganisms were coagulase-negative staphylococci (CoNS), E. coli, K. pneumoniae, P. aeruginosa and S. aureus. We found a significant increase in resistance to clindamycin and oxacillin for CoNS and significant decrease in nitrofurantoin and amikacin resistance for E. coli and K. pneumoniae. We observed a strong positive and statistically significant correlation between amikacin resistance prevalence and amikacin dispensed grams for P. aeruginosa (r = 0.95, p = 0.05). Conclusions: The antibiotic resistance profile showed by our study highlights the need of an appropriate antibiotic control use in the Hospital setting. Competing Interests: No Conflict of Interest is declared (Copyright (c) 2021 David Abraham Rosado-Rosado, Rafael Arias-Flores, Jose Guillermo Vazquez-Rosales, Roberto Joaquin Robles-Ramirez, Rodolfo del Campo-Ortega, Ivan de Jesus Ascencio-Montiel.) |
| Databáze: | MEDLINE |
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