Effects of Central Obesity on Esophageal Epithelial Barrier Function.

Autor:	Gibbens YY; Department of Medicine, Mayo Clinic, Rochester, Minnesota, USA., Lansing R; Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota, USA., Johnson ML; Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota, USA., Blevins CH; Division of Gastroenterology, Billings Clinic, Billings, Montana, USA., Katzka DA; Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota, USA., Iyer PG; Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota, USA.
Jazyk:	angličtina
Zdroj:	The American journal of gastroenterology [Am J Gastroenterol] 2021 Jul 01; Vol. 116 (7), pp. 1537-1541.
DOI:	10.14309/ajg.0000000000001196
Abstrakt:	Introduction: We assessed if obesity perturbs the esophageal epithelial barrier function independent of promotion of gastroesophageal reflux (GER). Methods: Thirty-eight participants were divided into 4 groups: Obesity-/GER-, Obesity+/GER-, Obesity-/GER+, and Obesity+/GER+. Esophageal intercellular space and desmosome density (structural integrity) and fluorescein leak (functional integrity) were measured. Results: The Obesity+/GER- group demonstrated increased intercellular space, reduced desmosome density, and increased fluorescein leak compared with control subjects. These changes were similar but not additive to findings seen in Obesity-/GER + and Obesity+/GER+ patients. Discussion: Central obesity impairs structural and functional integrity of the esophageal barrier independent of GER, likely predisposing to esophageal injury. (Copyright © 2021 by The American College of Gastroenterology.)
Databáze:	MEDLINE
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