Perioperative risk factors associated with delayed graft function following deceased donor kidney transplantation: A retrospective, single center study.

Autor:	Mendez NV; Department of Anesthesiology, University of Miami/Jackson Memorial Hospital, Miami, FL 33136, United States., Raveh Y; Department of Anesthesiology, University of Miami/Jackson Memorial Hospital, Miami, FL 33136, United States., Livingstone JJ; Department of Anesthesiology, University of Miami/Jackson Memorial Hospital, Miami, FL 33136, United States., Ciancio G; Department of Surgery, Miami Transplant Institute/University of Miami/Jackson Memorial Hospital, Miami, FL 33136, United States., Guerra G; Division of Nephrology of the Department of Medicine, University of Miami/Jackson Memorial Hospital, Miami, FL 33136, United States., Burke Iii GW; Department of Surgery, Miami Transplant Institute/University of Miami/Jackson Memorial Hospital, Miami, FL 33136, United States., Shatz VB; Department of Anesthesiology, University of Miami/Jackson Memorial Hospital, Miami, FL 33136, United States., Souki FG; Department of Anesthesiology, University of Miami/Jackson Memorial Hospital, Miami, FL 33136, United States., Chen LJ; Department of Surgery, Miami Transplant Institute/University of Miami/Jackson Memorial Hospital, Miami, FL 33136, United States., Morsi M; Department of Surgery, Miami Transplant Institute/University of Miami/Jackson Memorial Hospital, Miami, FL 33136, United States., Figueiro JM; Department of Surgery, Miami Transplant Institute/University of Miami/Jackson Memorial Hospital, Miami, FL 33136, United States., Ibrahim TM; Department of Surgery, Miami Transplant Institute/University of Miami/Jackson Memorial Hospital, Miami, FL 33136, United States., DeFaria WL; Department of Surgery, Miami Transplant Institute/University of Miami/Jackson Memorial Hospital, Miami, FL 33136, United States., Nicolau-Raducu R; Department of Anesthesiology, University of Miami/Jackson Memorial Hospital, Miami, FL 33136, United States. rxn256@miami.edu.
Jazyk:	angličtina
Zdroj:	World journal of transplantation [World J Transplant] 2021 Apr 18; Vol. 11 (4), pp. 114-128.
DOI:	10.5500/wjt.v11.i4.114
Abstrakt:	Background: There is an abundant need to increase the availability of deceased donor kidney transplantation (DDKT) to address the high incidence of kidney failure. Challenges exist in the utilization of higher risk donor organs into what appears to be increasingly complex recipients; thus the identification of modifiable risk factors associated with poor outcomes is paramount. Aim: To identify risk factors associated with delayed graft function (DGF). Methods: Consecutive adults undergoing DDKT between January 2016 and July 2017 were identified with a study population of 294 patients. The primary outcome was the occurrence of DGF. Results: The incidence of DGF was 27%. Under logistic regression, eight independent risk factors for DGF were identified including recipient body mass index ≥ 30 kg/m 2 , baseline mean arterial pressure < 110 mmHg, intraoperative phenylephrine administration, cold storage time ≥ 16 h, donation after cardiac death, donor history of coronary artery disease, donor terminal creatinine ≥ 1.9 mg/dL, and a hypothermic machine perfusion (HMP) pump resistance ≥ 0.23 mmHg/mL/min. Conclusion: We delineate the association between DGF and recipient characteristics of pre-induction mean arterial pressure below 110 mmHg, metabolic syndrome, donor-specific risk factors, HMP pump parameters, and intraoperative use of phenylephrine. Competing Interests: Conflict-of-interest statement: The authors of this manuscript have no conflicts of interest to disclose and no competing financial interest. (©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.)
Databáze:	MEDLINE
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