A higher De Ritis ratio (AST/ALT) is a risk factor for progression in high-risk non-muscle invasive bladder cancer.

Autor:	Fukui-Kawaura S; Department of Urology, Yokohama Minami Kyousai Hospital, Yokohama, Japan., Kawahara T; Department of Urology, Yokohama Minami Kyousai Hospital, Yokohama, Japan., Araki Y; Department of Urology, Yokohama Minami Kyousai Hospital, Yokohama, Japan., Nishimura R; Department of Urology, Yokohama Minami Kyousai Hospital, Yokohama, Japan., Uemura K; Department of Urology, Yokohama Minami Kyousai Hospital, Yokohama, Japan., Namura K; Department of Urology, Yokohama Minami Kyousai Hospital, Yokohama, Japan., Mizuno N; Department of Urology, Yokohama Minami Kyousai Hospital, Yokohama, Japan., Yao M; Department of Urology, Yokohama City University, Graduate School of Medicine, Yokohama, Japan., Uemura H; Departments of Urology and Renal Transplantation, Yokohama City University Medical Center, Yokohama, Japan., Ikeda I; Department of Urology, Yokohama Minami Kyousai Hospital, Yokohama, Japan.
Jazyk:	angličtina
Zdroj:	Oncotarget [Oncotarget] 2021 Apr 27; Vol. 12 (9), pp. 917-922. Date of Electronic Publication: 2021 Apr 27 (Print Publication: 2021).
DOI:	10.18632/oncotarget.27944
Abstrakt:	Background: High-risk non-muscle invasive bladder cancer (NMIBC) is thought to be associated with a higher risk of recurrence and progression. A recent study revealed that a high De Ritis ratio was a risk factor in some solid malignancies. This study examined the importance of the De Ritis ratio as a prognostic marker in high-risk NMIBC. Materials and Methods: A total of 138 patients who were initially diagnosed with high-risk NMIBC between January 2012 to December 2016 were enrolled in this study. The criteria for the high-risk classification followed the EAU guidelines. The recurrence-free and progression-free survival of the higher and lower De Ritis ratio groups were compared. The cut-off value of the De Ritis ratio was set at 1.35, based on a receiver operator curve analysis. Results: The median observation period was 50.3 months. Among these patients, 32 (23.1%) patients developed recurrent disease and 15 (10.9%) patients showed progression. A multivariate analysis revealed that non-BCG treatment was an independent risk factor for recurrence, and a higher De Ritis ratio was an independent risk factor for cancer progression. Conclusions: The De Ritis ratio might be a risk factor for progression in high-risk NMIBC. Competing Interests: CONFLICTS OF INTEREST Authors have no conflicts of interest to declare. (Copyright: © 2021 Fukui-Kawaura et al.)
Databáze:	MEDLINE
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