Mesenchymal Stem/Progenitor Cells: The Prospect of Human Clinical Translation.

Autor: Rady D; Oral Biology Department, Faculty of Dentistry, Cairo University, Cairo, Egypt.; Stem Cells and Tissue Engineering Research Group, Faculty of Dentistry, Cairo University, Cairo, Egypt., Abbass MMS; Oral Biology Department, Faculty of Dentistry, Cairo University, Cairo, Egypt.; Stem Cells and Tissue Engineering Research Group, Faculty of Dentistry, Cairo University, Cairo, Egypt., El-Rashidy AA; Stem Cells and Tissue Engineering Research Group, Faculty of Dentistry, Cairo University, Cairo, Egypt.; Biomaterials Department, Faculty of Dentistry, Cairo University, Cairo, Egypt., El Moshy S; Oral Biology Department, Faculty of Dentistry, Cairo University, Cairo, Egypt.; Stem Cells and Tissue Engineering Research Group, Faculty of Dentistry, Cairo University, Cairo, Egypt., Radwan IA; Oral Biology Department, Faculty of Dentistry, Cairo University, Cairo, Egypt.; Stem Cells and Tissue Engineering Research Group, Faculty of Dentistry, Cairo University, Cairo, Egypt., Dörfer CE; Clinic for Conservative Dentistry and Periodontology, School of Dental Medicine, Christian Albrechts University, Kiel, Germany., Fawzy El-Sayed KM; Stem Cells and Tissue Engineering Research Group, Faculty of Dentistry, Cairo University, Cairo, Egypt.; Clinic for Conservative Dentistry and Periodontology, School of Dental Medicine, Christian Albrechts University, Kiel, Germany.; Oral Medicine and Periodontology Department, Faculty of Dentistry, Cairo University, Cairo, Egypt.
Jazyk: angličtina
Zdroj: Stem cells international [Stem Cells Int] 2020 Aug 11; Vol. 2020, pp. 8837654. Date of Electronic Publication: 2020 Aug 11 (Print Publication: 2020).
DOI: 10.1155/2020/8837654
Abstrakt: Mesenchymal stem/progenitor cells (MSCs) are key players in regenerative medicine, relying principally on their differentiation/regeneration potential, immunomodulatory properties, paracrine effects, and potent homing ability with minimal if any ethical concerns. Even though multiple preclinical and clinical studies have demonstrated remarkable properties for MSCs, the clinical applicability of MSC-based therapies is still questionable. Several challenges exist that critically hinder a successful clinical translation of MSC-based therapies, including but not limited to heterogeneity of their populations, variability in their quality and quantity, donor-related factors, discrepancies in protocols for isolation, in vitro expansion and premodification, and variability in methods of cell delivery, dosing, and cell homing. Alterations of MSC viability, proliferation, properties, and/or function are also affected by various drugs and chemicals. Moreover, significant safety concerns exist due to possible teratogenic/neoplastic potential and transmission of infectious diseases. Through the current review, we aim to highlight the major challenges facing MSCs' human clinical translation and shed light on the undergoing strategies to overcome them.
Competing Interests: All authors declare that they do not have any conflict of interest related to this work.
(Copyright © 2020 Dina Rady et al.)
Databáze: MEDLINE
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