A dual-target molecular mechanism of pyrethrum repellency against mosquitoes.

Autor: Liu F; Department of Entomology, Michigan State University, East Lansing, MI, USA., Wang Q; Department of Entomology, Michigan State University, East Lansing, MI, USA.; Department of Preventive Medicine and Public Health Laboratory Science, School of Medicine, Jiangsu University, Zhenjiang, Jiangsu, China., Xu P; Department of Entomology, Michigan State University, East Lansing, MI, USA., Andreazza F; Department of Entomology, Michigan State University, East Lansing, MI, USA.; Department of Entomology, Universidade Federal de Viçosa, Viçosa, MG, Brazil.; Department of Biology, Duke University, Durham, NC, USA., Valbon WR; Department of Entomology, Michigan State University, East Lansing, MI, USA.; Department of Entomology, Universidade Federal de Viçosa, Viçosa, MG, Brazil.; Department of Biology, Duke University, Durham, NC, USA., Bandason E; Department of Entomology, Michigan State University, East Lansing, MI, USA., Chen M; Institute of Pesticide and Environmental Toxicology, Zhejiang University, Hangzhou, China., Yan R; Institute of Pesticide and Environmental Toxicology, Zhejiang University, Hangzhou, China., Feng B; Department of Entomology, Michigan State University, East Lansing, MI, USA.; Institute of Health and Environment, Wenzhou Medical University, Wenzhou, China., Smith LB; Department of Entomology, Cornell University, Ithaca, NY, USA., Scott JG; Department of Entomology, Cornell University, Ithaca, NY, USA., Takamatsu G; Department of Applied Biological Chemistry, Faculty of Agriculture, Kindai University, Nakamachi, Nara, Japan., Ihara M; Department of Applied Biological Chemistry, Faculty of Agriculture, Kindai University, Nakamachi, Nara, Japan., Matsuda K; Department of Applied Biological Chemistry, Faculty of Agriculture, Kindai University, Nakamachi, Nara, Japan., Klimavicz J; Department of Entomology, Iowa State University, Ames, IA, USA., Coats J; Department of Entomology, Iowa State University, Ames, IA, USA., Oliveira EE; Department of Entomology, Michigan State University, East Lansing, MI, USA.; Department of Entomology, Universidade Federal de Viçosa, Viçosa, MG, Brazil., Du Y; Department of Entomology, Michigan State University, East Lansing, MI, USA., Dong K; Department of Entomology, Michigan State University, East Lansing, MI, USA. ke.dong@duke.edu.; Department of Biology, Duke University, Durham, NC, USA. ke.dong@duke.edu.
Jazyk: angličtina
Zdroj: Nature communications [Nat Commun] 2021 May 05; Vol. 12 (1), pp. 2553. Date of Electronic Publication: 2021 May 05.
DOI: 10.1038/s41467-021-22847-0
Abstrakt: Pyrethrum extracts from flower heads of Chrysanthemum spp. have been used worldwide in insecticides and repellents. While the molecular mechanisms of its insecticidal action are known, the molecular basis of pyrethrum repellency remains a mystery. In this study, we find that the principal components of pyrethrum, pyrethrins, and a minor component, (E)-β-farnesene (EBF), each activate a specific type of olfactory receptor neurons in Aedes aegypti mosquitoes. We identify Ae. aegypti odorant receptor 31 (AaOr31) as a cognate Or for EBF and find that Or31-mediated repellency is significantly synergized by pyrethrin-induced activation of voltage-gated sodium channels. Thus, pyrethrum exerts spatial repellency through a novel, dual-target mechanism. Elucidation of this two-target mechanism may have potential implications in the design and development of a new generation of synthetic repellents against major mosquito vectors of infectious diseases.
Databáze: MEDLINE
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