| Autor: |
Guo Q; School of Chemistry, Sun Yat-sen University, Guangzhou, People's Republic of China., Dai XM; School of Chemistry, Sun Yat-sen University, Guangzhou, People's Republic of China., Lan WJ; School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, People's Republic of China., Chen LP; School of Chemistry, Sun Yat-sen University, Guangzhou, People's Republic of China., Lam CK; School of Chemistry, Sun Yat-sen University, Guangzhou, People's Republic of China., Feng GK; State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Cancer Center, Sun Yat-sen University, Guangzhou, People's Republic of China., Deng R; State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Cancer Center, Sun Yat-sen University, Guangzhou, People's Republic of China., Zhu XF; State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Cancer Center, Sun Yat-sen University, Guangzhou, People's Republic of China., Li HJ; School of Chemistry, Sun Yat-sen University, Guangzhou, People's Republic of China. |
| Abstrakt: |
Amino acid-directed strategy becomes an efficient way to explore the alkaloids' biosynthetic potential of marine fungi. The metabolites of marine fungus Monascus albidus BB3 were regulated obviously when cultured in GPY medium supplemented with L-tryptophan, L-phenylalanine, D,L-methionine, L-threonine, L-lysine, L-serine and L-valine. Four new γ-lactams, monascuslactams A-D ( 1 - 4 ), together with two known compounds pulchellalactam ( 5 ) and O -acetylperlolyrine ( 6 ) were obtained. Their structures were determined by comprehensive analysis on the 1 D and 2 D NMR, HRESIMS, UV and IR data, and their absolute configurations were assigned by the experimental and calculated ECD data analysis. Compounds 3 , 4 and 6 showed moderate cytotoxicity against human cancer cell lines SUNE1, HepG2, QGY7701, GLC82, HCT116 and MDA-MB-231. |
