Adult systemic lupus erythematosus in Egypt: The nation-wide spectrum of 3661 patients and world-wide standpoint.

Autor: Gheita TA; Rheumatology Department, Faculty of Medicine, Cairo University, Cairo, Egypt., Noor RA; Internal Medicine Department, Rheumatology Unit, Tanta University, Gharbia, Egypt., Abualfadl E; Rheumatology Department, Faculty of Medicine, Sohag University, Sohag, Egypt.; Qena/Luxor Hospitals, Qena, Egypt., Abousehly OS; Rheumatology Department, Faculty of Medicine, Sohag University, Sohag, Egypt., El-Gazzar II; Rheumatology Department, Faculty of Medicine, Cairo University, Cairo, Egypt., El Shereef RR; Rheumatology Department, Faculty of Medicine, Minia University, Minia, Egypt., Senara S; Rheumatology Department, Faculty of Medicine, Fayoum University, Fayoum, Egypt., Abdalla AM; Rheumatology Department, Faculty of Medicine, Aswan University, Aswan, Egypt., Khalil NM; Internal Medicine Department, Rheumatology Unit, Faculty of Medicine, Cairo University, Cairo, Egypt., ElSaman AM; Rheumatology Department, Faculty of Medicine, Sohag University, Sohag, Egypt., Tharwat S; Rheumatology Unit, Internal Medicine, Mansoura University, Dakahlia, Egypt., Nasef SI; Rheumatology Department, Faculty of Medicine, Suez-Canal University, Ismailia, Egypt., Mohamed EF; Internal Medicine Department, Rheumatology Unit, Faculty of Medicine (Girls), Al-Azhar University, Cairo, Egypt., Noshy N; Internal Medicine Department, Rheumatology Unit, Faculty of Medicine, Ain-Shams University, Cairo, Egypt., El-Essawi DF; Internal Medicine Department, Rheumatology Unit, Egyptian Atomic Energy Authority (EAEA), Cairo, Egypt., Moshrif AH; Rheumatology Department, Faculty of Medicine, Al-Azhar University, Assuit, Egypt., Fawzy RM; Rheumatology Department, Faculty of Medicine, Benha University, Kalubia, Egypt., El-Najjar AR; Rheumatology Department, Faculty of Medicine, Zagazig University, Sharkia, Egypt., Hammam N; Rheumatology Department, Faculty of Medicine, Assuit University, Assuit, Egypt.; Rheumatology Department, University of California San Francisco (UCSF), San Francisco, CA, USA., Ismail F; Rheumatology Department, Faculty of Medicine, Minia University, Minia, Egypt., ElKhalifa M; Internal Medicine Department, Rheumatology Unit, Faculty of Medicine, Alexandria University, Alexandria, Egypt., Samy N; Internal Medicine Department, Rheumatology Unit, Faculty of Medicine, Ain-Shams University, Cairo, Egypt., Hassan E; Internal Medicine Department, Rheumatology Unit, Faculty of Medicine, Alexandria University, Alexandria, Egypt., Abaza NM; Rheumatology Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt., ElShebini E; Internal Medicine Department, Rheumatology Unit, Menoufiya University, Menoufiya, Egypt., Fathi HM; Rheumatology Department, Faculty of Medicine, Fayoum University, Fayoum, Egypt., Salem MN; Internal Medicine Department, Rheumatology Unit, Faculty of Medicine, Beni-Suef University, Beni-Suef, Egypt., Abdel-Fattah YH; Rheumatology Department, Faculty of Medicine, Alexandria University, Alexandria, Egypt., Saad E; Rheumatology Department, Faculty of Medicine, South Valley University, Qena, Egypt., Abd Elazim MI; Rheumatology Department, Faculty of Medicine, Beni-Suef University, Beni-Suef, Egypt., Eesa NN; Rheumatology Department, Faculty of Medicine, Cairo University, Cairo, Egypt., El-Bahnasawy AS; Rheumatology Department, Faculty of Medicine, Mansoura University, Dakahlia, Egypt., El-Hammady DH; Rheumatology Department, Faculty of Medicine, Helwan University, Cairo, Egypt., El-Shanawany AT; Rheumatology Department, Faculty of Medicine, Menoufiya University, Menoufiya, Egypt., Ibrahim SE; Rheumatology Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt., Said EA; Rheumatology Department, Faculty of Medicine, Benha University, Kalubia, Egypt., El-Saadany HM; Rheumatology Department, Faculty of Medicine, Tanta University, Gharbia, Egypt., Selim ZI; Rheumatology Department, Faculty of Medicine, Assuit University, Assuit, Egypt., Fawzy SM; Rheumatology Department, Faculty of Medicine, Cairo University, Cairo, Egypt., Raafat HA; Rheumatology Department, Faculty of Medicine, Cairo University, Cairo, Egypt.
Jazyk: angličtina
Zdroj: Lupus [Lupus] 2021 Aug; Vol. 30 (9), pp. 1526-1535. Date of Electronic Publication: 2021 May 06.
DOI: 10.1177/09612033211014253
Abstrakt: Objective: The aim of this study was to present the epidemiology, clinical manifestations and treatment pattern of systemic lupus erythematosus (SLE) in Egyptian patients over the country and compare the findings to large cohorts worldwide. Objectives were extended to focus on the age at onset and gender driven influence on the disease characteristics.
Patients and Method: This population-based, multicenter, cross-sectional study included 3661 adult SLE patients from Egyptian rheumatology departments across the nation. Demographic, clinical, and therapeutic data were assessed for all patients.
Results: The study included 3661 patients; 3296 females and 365 males (9.03:1) and the median age was 30 years (17-79 years), disease duration 4 years (0-75 years) while the median age at disease onset was 25 years (4-75 years). The overall estimated prevalence of adult SLE in Egypt was 6.1/100,000 population (1.2/100,000 males and 11.3/100,000 females).There were 316 (8.6%) juvenile-onset (Jo-SLE) and 3345 adult-onset (Ao-SLE). Age at onset was highest in South and lowest in Cairo (p < 0.0001).
Conclusion: SLE in Egypt had a wide variety of clinical and immunological manifestations, with some similarities with that in other nations and differences within the same country. The clinical characteristics, autoantibodies and comorbidities are comparable between Ao-SLE and Jo-SLE. The frequency of various clinical and immunological manifestations varied between gender. Additional studies are needed to determine the underlying factors contributing to gender and age of onset differences.
Databáze: MEDLINE
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