Early-onset climacterium is not associated with impaired vitamin D status: a population-based study.

Autor:	Lumme JE; PEDEGO Research Unit, University of Oulu, Oulu, Finland.; Department of Obstetrics and Gynecology, Oulu University Hospital, Oulu, Finland.; Medical Research Centre Oulu, Oulu University Hospital and University of Oulu, Oulu, Finland., Savukoski SM; PEDEGO Research Unit, University of Oulu, Oulu, Finland.; Department of Obstetrics and Gynecology, Oulu University Hospital, Oulu, Finland.; Medical Research Centre Oulu, Oulu University Hospital and University of Oulu, Oulu, Finland., Suvanto ETJ; PEDEGO Research Unit, University of Oulu, Oulu, Finland.; Department of Obstetrics and Gynecology, Oulu University Hospital, Oulu, Finland.; Medical Research Centre Oulu, Oulu University Hospital and University of Oulu, Oulu, Finland., Pesonen PRO; Infrastructure for Population Studies, Faculty of Medicine, University of Oulu, Oulu, Finland., Auvinen JP; Medical Research Centre Oulu, Oulu University Hospital and University of Oulu, Oulu, Finland.; Centre for Life Course Health Research, University of Oulu, Oulu, Finland.; Oulunkaari Health Center, Ii, Finland., Sebert S; Centre for Life Course Health Research, University of Oulu, Oulu, Finland.; Department of Epidemiology and Biostatistics, MRC Centre for Environment and Health, School of Public Health, Imperial College, London, UK., Hyppönen E; Australian Centre for Precision Health, University of South Australia, Cancer Research Institute, Adelaide, Australia.; Unit of Clinical and Health Sciences, University of South Australia, Adelaide, Australia.; South Australian Health and Medical Research Institute, Adelaide, Australia., Järvelin MR; Centre for Life Course Health Research, University of Oulu, Oulu, Finland.; Department of Epidemiology and Biostatistics, MRC Centre for Environment and Health, School of Public Health, Imperial College, London, UK.; Biocenter Oulu, University of Oulu, Oulu, Finland.; Department of Life Sciences, College of Health and Life Sciences, Brunel University London Kingston Lane, Uxbridge, Middlesex, UK., Puukka KS; Medical Research Centre Oulu, Oulu University Hospital and University of Oulu, Oulu, Finland.; NordLab Oulu, Oulu University Hospital, Oulu, Finland.; Department of Clinical Chemistry, University of Oulu, Oulu, Finland., Herzig KH; Medical Research Centre Oulu, Oulu University Hospital and University of Oulu, Oulu, Finland.; Institute of Biomedicine, University of Oulu, Oulu, Finland.; Department of Gastroenterology and Metabolism, Poznan University of Medical Sciences, Poznan, Poland., Oura P; Medical Research Centre Oulu, Oulu University Hospital and University of Oulu, Oulu, Finland.; Centre for Life Course Health Research, University of Oulu, Oulu, Finland., Ojaniemi M; PEDEGO Research Unit, University of Oulu, Oulu, Finland.; Medical Research Centre Oulu, Oulu University Hospital and University of Oulu, Oulu, Finland.; Department of Pediatrics and Adolescence, Oulu University Hospital, Oulu, Finland., Niinimäki M; PEDEGO Research Unit, University of Oulu, Oulu, Finland.; Department of Obstetrics and Gynecology, Oulu University Hospital, Oulu, Finland.; Medical Research Centre Oulu, Oulu University Hospital and University of Oulu, Oulu, Finland.
Jazyk:	angličtina
Zdroj:	Menopause (New York, N.Y.) [Menopause] 2021 May 03; Vol. 28 (8), pp. 899-908. Date of Electronic Publication: 2021 May 03.
DOI:	10.1097/GME.0000000000001781
Abstrakt:	Objective: To investigate vitamin D status in women with the onset of the climacteric phase by age 46 as both early menopause and inadequate vitamin D status may increase the risk of adverse health outcomes. Methods: A cross-sectional study included 2,544, 46-year-old women from a birth cohort. Women were divided into the following two groups according to their menstrual history and follicle-stimulating hormone (FSH) concentration: 1) climacteric (FSH ≥25 IU/L and amenorrhea ≥4 mo, n = 351) and 2) preclimacteric women (FSH <25 IU/L and having regular/irregular menstrual cycles, n = 2,193). Serum 25-hydroxyvitamin D (25(OH)D) concentrations were compared between the groups. A linear regression model was performed to investigate which factors are associated with 25(OH)D status. Results: Mean serum 25(OH)D concentrations were higher in climacteric compared with preclimacteric women (68.1 ± 19.8 nmol/L vs 65.2 ± 19.3 nmol/L, P = 0.01). However, in the linear regression model, climacteric status was not associated with 25(OH)D status (multivariable adjusted mean difference 4.5 nmol/L, 95% confidence interval -1.4 to 10.4, P = 0.137). A total of 76 of the climacteric women were using systemic estrogen hormone therapy (HT). In a subanalysis, including only climacteric women, the use of HT was associated with higher 25(OH)D status (multivariable adjusted mean difference 5.9 nmol/L, 95% confidence interval 1.3-10.5, P = 0.013). Conclusions: The onset of the climacteric phase by age 46 was not associated with inadequate 25(OH)D concentrations, whereas HT use was associated with higher 25(OH)D status in women with early-onset climacterium. Competing Interests: Financial disclosures/conflicts of interest: E.H. has received grants from National Health and Medical Research Council, Australian Research Council, Tour de Cure, and Medical Research Future Fund. The rest of the authors have nothing to disclose. (Copyright © 2021 by The North American Menopause Society.)
Databáze:	MEDLINE
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