Examining the Potential Formation of Ternary Chromium-Histidine-DNA Complexes and Implications for Their Carcinogenicity.

Autor: Lankford E; Department of Chemistry and Biochemistry, The University of Alabama, Tuscaloosa, AL, 35487-0336, USA., Thomas CS; Department of Chemistry and Biochemistry, The University of Alabama, Tuscaloosa, AL, 35487-0336, USA., Marchi S; Department of Chemistry and Biochemistry, The University of Alabama, Tuscaloosa, AL, 35487-0336, USA., Brown S; Department of Chemistry and Biochemistry, The University of Alabama, Tuscaloosa, AL, 35487-0336, USA., Woski SA; Department of Chemistry and Biochemistry, The University of Alabama, Tuscaloosa, AL, 35487-0336, USA., Vincent JB; Department of Chemistry and Biochemistry, The University of Alabama, Tuscaloosa, AL, 35487-0336, USA. jvincent@ua.edu.
Jazyk: angličtina
Zdroj: Biological trace element research [Biol Trace Elem Res] 2022 Mar; Vol. 200 (3), pp. 1473-1481. Date of Electronic Publication: 2021 May 04.
DOI: 10.1007/s12011-021-02743-w
Abstrakt: The mutagenic and carcinogenic properties of chromium(VI) complexes have been ascribed to the formation of ternary Cr(III)-small molecule-DNA complexes. As part of these laboratories efforts to establish the structure and properties of discrete binary and ternary adducts of Cr(III) and DNA at a molecular level, the properties of Cr(III)-histidine-DNA complexes formed from Cr(III) were examined. These studies determined the composition of previously described "prereacted" chromium histidinate and reveal the reaction of "prereacted" chromium histidinate with DNA does not form ternary complexes as previously proposed. The products instead are chromium histidinate complexes weakly bound, probably in the minor groove, to DNA. These weakly bound adducts cannot be responsible for the mutagenic and carcinogenic properties ascribed to ternary Cr(III)-histidine-DNA adducts. The results of biological studies where "ternary adducts" of Cr(III), histidine, and DNA were made from "prereacted" chromium histidinate must, therefore, be interpreted with caution.
(© 2021. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)
Databáze: MEDLINE
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