Conjugal inflammatory bowel disease: a systematic review and European survey.

Autor:	Costa-Santos MP; Division of Gastroenterology, Hospital Beatriz Ângelo, Loures, Portugal (Maria Pia Costa-Santos, Catarina Frias-Gomes, António Oliveira, Joana Torres)., Frias-Gomes C; Division of Gastroenterology, Hospital Beatriz Ângelo, Loures, Portugal (Maria Pia Costa-Santos, Catarina Frias-Gomes, António Oliveira, Joana Torres)., Oliveira A; Division of Gastroenterology, Hospital Beatriz Ângelo, Loures, Portugal (Maria Pia Costa-Santos, Catarina Frias-Gomes, António Oliveira, Joana Torres)., Sabino J; Division of Gastroenterology, University Hospital of Leuven, Leuven, Belgium (João Sabino)., Mañosa M; Division of Gastroenterology, Hospital Universitari Germans Trias i Pujol, Badalona, Spain (Miriam Mañosa)., Ellul P; Division of Gastroenterology, Mater Dei Hospital, Malta (Pierre Ellul)., Sampaio A; Portuguese Association of Inflammatory Bowel Disease (APDI) (Ana Sampaio)., Avedano L; European Federation of Crohn's & Ulcerative Colitis Associations (EFCCA) (Luisa Avedano, Salvo Leone)., Leone S; European Federation of Crohn's & Ulcerative Colitis Associations (EFCCA) (Luisa Avedano, Salvo Leone)., Colombel JF; Division of Gastroenterology, Icahn School of Medicine at Mount Sinai, New York City, NY, USA (Jean-Frédéric Colombel)., Torres J; Division of Gastroenterology, Hospital Beatriz Ângelo, Loures, Portugal (Maria Pia Costa-Santos, Catarina Frias-Gomes, António Oliveira, Joana Torres).
Jazyk:	angličtina
Zdroj:	Annals of gastroenterology [Ann Gastroenterol] 2021; Vol. 34 (3), pp. 361-369. Date of Electronic Publication: 2021 Feb 26.
DOI:	10.20524/aog.2021.0598
Abstrakt:	Background: The frequency of inflammatory bowel disease (IBD) is increased after marriage to an individual with the disease. Importantly, the offspring of these couples have a significant risk for developing the disease. Herein, we aimed to better characterize conjugal IBD. Methods: A systematic literature search was conducted with predetermined search criteria. Relevant manuscripts reporting on couples with IBD and their offspring were selected. Concomitantly, a cross-sectional survey was conducted of couples where both members were affected with IBD, as well as their offspring, and electronically distributed by patients' associations. Results: We identified 20 reports of IBD in couples, for a total of 68 couples. Of these, 66% were concordant regarding IBD type and 66% were diagnosed after cohabitation. The overall prevalence of IBD in the offspring of these couples was 29%. Our survey identified 58 couples with IBD, with 62% being concordant regarding IBD type; 42.9% were diagnosed prior to cohabitation, in 12.5% one spouse was diagnosed before and the other after cohabitation, and in 44.6% the onset of disease occurred after cohabitation for both. The prevalence of IBD in children born from these couples was 10%. The probability of developing disease in the progeny was 2% at 10 years, 12% at 15 years, and 16% at 20 years of age. Conclusions: IBD in couples occurs mostly after marriage to an individual with disease or after many years of cohabitation. In a modern cohort, the risk for the progeny was around 16% by the age of 20, lower than previously reported. Competing Interests: Conflict of Interest: None (Copyright: © 2021 Hellenic Society of Gastroenterology.)
Databáze:	MEDLINE
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