| Autor: |
Engelke DS; Department of Neurobiology and Anatomy, The University of Texas Health Science Center, Houston, TX, USA., Zhang XO; Department of Neurobiology and Anatomy, The University of Texas Health Science Center, Houston, TX, USA., O'Malley JJ; Department of Neurobiology and Anatomy, The University of Texas Health Science Center, Houston, TX, USA., Fernandez-Leon JA; Department of Neurobiology and Anatomy, The University of Texas Health Science Center, Houston, TX, USA., Li S; Department of Oral Biol., University of Manitoba, Winnipeg, MB, Canada., Kirouac GJ; Department of Oral Biol., University of Manitoba, Winnipeg, MB, Canada., Beierlein M; Department of Neurobiology and Anatomy, The University of Texas Health Science Center, Houston, TX, USA., Do-Monte FH; Department of Neurobiology and Anatomy, The University of Texas Health Science Center, Houston, TX, USA. fabricio.h.domonte@uth.tmc.edu. |
| Abstrakt: |
Survival depends on a balance between seeking rewards and avoiding potential threats, but the neural circuits that regulate this motivational conflict remain largely unknown. Using an approach-food vs. avoid-predator threat conflict test in rats, we identified a subpopulation of neurons in the anterior portion of the paraventricular thalamic nucleus (aPVT) which express corticotrophin-releasing factor (CRF) and are preferentially recruited during conflict. Inactivation of aPVT CRF neurons during conflict biases animal's response toward food, whereas activation of these cells recapitulates the food-seeking suppression observed during conflict. aPVT CRF neurons project densely to the nucleus accumbens (NAc), and activity in this pathway reduces food seeking and increases avoidance. In addition, we identified the ventromedial hypothalamus (VMH) as a critical input to aPVT CRF neurons, and demonstrated that VMH-aPVT neurons mediate defensive behaviors exclusively during conflict. Together, our findings describe a hypothalamic-thalamostriatal circuit that suppresses reward-seeking behavior under the competing demands of avoiding threats. |
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