| Autor: |
Scărlătescu AI; Department of Cardiology, 'Carol Davila' University of Medicine and Pharmacy, 050474 Bucharest, Romania.; Department of Cardiology, Clinical Emergency Hospital of Bucharest, 014461 Bucharest, Romania., Micheu MM; Department of Cardiology, Clinical Emergency Hospital of Bucharest, 014461 Bucharest, Romania., Popa-Fotea NM; Department of Cardiology, 'Carol Davila' University of Medicine and Pharmacy, 050474 Bucharest, Romania.; Department of Cardiology, Clinical Emergency Hospital of Bucharest, 014461 Bucharest, Romania., Dorobanțu M; Department of Cardiology, 'Carol Davila' University of Medicine and Pharmacy, 050474 Bucharest, Romania.; Department of Cardiology, Clinical Emergency Hospital of Bucharest, 014461 Bucharest, Romania. |
| Abstrakt: |
Despite diagnostic and therapeutic advances, coronary artery disease and especially its extreme manifestation, ST elevation myocardial infarction (STEMI), remain the leading causes of morbidity and mortality worldwide. Early and prompt diagnosis is of great importance regarding the prognosis of STEMI patients. In recent years, microRNAs (miRNAs) have emerged as promising tools involved in many pathophysiological processes in various fields, including cardiovascular diseases. In acute coronary syndromes (ACS), circulating levels of miRNAs are significantly elevated, as an indicator of cardiac damage, making them a promising marker for early diagnosis of myocardial infarction. They also have prognostic value and great potential as therapeutic targets considering their key function in gene regulation. This review aims to summarize current information about miRNAs and their role as diagnostic, prognostic and therapeutic targets in STEMI patients. |
