Innate and acquired immune responses of colostrum-fed neonatal Holstein calves following intranasal vaccination with two commercially available modified-live virus vaccines.
| Autor: | Midla LT, Hill KL, Van Engen NK, Edmonds M, Renter DG, Streeter MN, Hutcheson JP, Griebel PJ |
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| Jazyk: | angličtina |
| Zdroj: | Journal of the American Veterinary Medical Association [J Am Vet Med Assoc] 2021 May 15; Vol. 258 (10), pp. 1119-1129. |
| DOI: | 10.2460/javma.258.10.1119 |
| Abstrakt: | Objective: To compare immune responses induced by 2 commercially available vaccines with a bovine herpesvirus type 1 (BHV1) component following intranasal (IN) administration to colostrum-fed calves. Animals: 90 male Holstein calves (ages, 5 to 14 days). Procedures: In a randomized complete block design, each calf received 2 mL (1 mL/nostril) of vaccine A (n = 30), vaccine B (30), or saline (0.9% NaCl) solution (30) on day 0. Blood samples were collected for determination of serum anti-BHV1 IgG titer, and nasal fluid (NF) samples were collected for determination of interferon (IFN)-α and IFN-γ concentrations and for secretory IgA titers against BHV1, Mannheimia haemolytica , and Pasteurella multocida at predetermined times for 42 days after vaccination. Results: All calves were seropositive for anti-BHV1 IgG, and the mean anti-BHV1 IgG titer did not differ significantly among the 3 groups at any time. Both vaccines induced significant transient increases in NF IFN-α and IFN-γ concentrations. On day 5, mean IFN-α concentration and the proportion of calves with detectable IFN-α concentrations for the vaccine A group were significantly greater than those for the vaccine B and control groups. On day 42, the mean NF anti- P multocida IgA titers for both vaccine groups were significantly greater than that of the control group. Conclusions and Clinical Relevance: Both vaccines induced innate and acquired immune responses in calves with colostral antibodies. The magnitude of the IFN-α response and proportion of calves with detectable IFN-α differed between the 2 vaccine groups. Both vaccines appeared to enhance the IgA response against P multocida . |
| Databáze: | MEDLINE |
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