Donor-defined mesenchymal stem cell antimicrobial potency against nontuberculous mycobacterium.

Autor: Bonfield TL; Department of Genetics and Genome Sciences, Case Western Reserve University, Cleveland, Ohio, USA.; National Center for Regenerative Medicine, Case Western Reserve University, Cleveland, Ohio, USA.; Department of Pediatrics, Case Western Reserve University, Cleveland, Ohio, USA., Sutton MT; Department of Genetics and Genome Sciences, Case Western Reserve University, Cleveland, Ohio, USA.; National Center for Regenerative Medicine, Case Western Reserve University, Cleveland, Ohio, USA.; Department of Pediatrics, Case Western Reserve University, Cleveland, Ohio, USA.; St. Jude Children's Research Hospital Graduate School of Biomedical Sciences, Memphis, Tennessee, USA., Fletcher DR; Department of Genetics and Genome Sciences, Case Western Reserve University, Cleveland, Ohio, USA.; National Center for Regenerative Medicine, Case Western Reserve University, Cleveland, Ohio, USA.; Department of Pediatrics, Case Western Reserve University, Cleveland, Ohio, USA., Folz MA; Department of Genetics and Genome Sciences, Case Western Reserve University, Cleveland, Ohio, USA.; National Center for Regenerative Medicine, Case Western Reserve University, Cleveland, Ohio, USA.; Department of Pediatrics, Case Western Reserve University, Cleveland, Ohio, USA., Ragavapuram V; Department of Genetics and Genome Sciences, Case Western Reserve University, Cleveland, Ohio, USA.; National Center for Regenerative Medicine, Case Western Reserve University, Cleveland, Ohio, USA.; Department of Pediatrics, Case Western Reserve University, Cleveland, Ohio, USA., Somoza RA; Department of Biology, Skeletal Research Center, Case Western Reserve University, Cleveland, Ohio, USA., Caplan AI; Department of Biology, Skeletal Research Center, Case Western Reserve University, Cleveland, Ohio, USA.
Jazyk: angličtina
Zdroj: Stem cells translational medicine [Stem Cells Transl Med] 2021 Aug; Vol. 10 (8), pp. 1202-1216. Date of Electronic Publication: 2021 May 04.
DOI: 10.1002/sctm.20-0521
Abstrakt: Chronic nontuberculous mycobacterial infections with Mycobacterium avium and Mycobacterium intracellulare complicate bronchiectasis, chronic obstructive airway disease, and the health of aging individuals. These insidious intracellular pathogens cause considerable morbidity and eventual mortality in individuals colonized with these bacteria. Current treatment regimens with antibiotic macrolides are both toxic and often inefficient at providing infection resolution. In this article, we demonstrate that human marrow-derived mesenchymal stem cells are antimicrobial and anti-inflammatory in vitro and in the context of an in vivo sustained infection of either M. avium and/or M. intracellulare.
(© 2021 The Authors. STEM CELLS TRANSLATIONAL MEDICINE published by Wiley Periodicals LLC on behalf of AlphaMed Press.)
Databáze: MEDLINE
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