Challenges, experiences, and postoperative outcomes in setting up first successful lung transplant unit in India.

Autor:	Rahulan V; Institute of Heart and Lung Transplant, Gleneagles Global Health City, Chennai, Tamil Nadu, India., Shah U; Institute of Heart and Lung Transplant, Gleneagles Global Health City, Chennai, Tamil Nadu, India., Yadav P; Institute of Heart and Lung Transplant, Gleneagles Global Health City, Chennai, Tamil Nadu, India., Ravipathy S; Institute of Heart and Lung Transplant, Gleneagles Global Health City, Chennai, Tamil Nadu, India., Jindal A; Institute of Heart and Lung Transplant, Gleneagles Global Health City, Chennai, Tamil Nadu, India., Suresh S; Institute of Heart and Lung Transplant, Gleneagles Global Health City, Chennai, Tamil Nadu, India., Sandeepa HS; Department of Pulmonology, BGS Global Hospital, Bengaluru, Karnataka, India., Kumar P; Institute of Heart and Lung Transplant, Gleneagles Global Health City, Chennai, Tamil Nadu, India., Mohandas A; Institute of Heart and Lung Transplant, Gleneagles Global Health City, Chennai, Tamil Nadu, India., Kumar S; Institute of Heart and Lung Transplant, Gleneagles Global Health City, Chennai, Tamil Nadu, India., Shivanna S; Institute of Heart and Lung Transplant, Gleneagles Global Health City, Chennai, Tamil Nadu, India., Kori S; Department of CTVS, BGS Global Hospital, Bengaluru, Karnataka, India., Dutta P; Institute of Heart and Lung Transplant, Gleneagles Global Health City, Chennai, Tamil Nadu, India., Anand P; Institute of Heart and Lung Transplant, Gleneagles Global Health City, Chennai, Tamil Nadu, India., Mahesh BN; Institute of Heart and Lung Transplant, Gleneagles Global Health City, Chennai, Tamil Nadu, India., Madhusudana N; Department of CTVS, BGS Global Hospital, Bengaluru, Karnataka, India., Bhaskar BV; Department of CTVS, BGS Global Hospital, Bengaluru, Karnataka, India., Balasubramani G; Institute of Heart and Lung Transplant, Gleneagles Global Health City, Chennai, Tamil Nadu, India., Attawar S; Institute of Heart and Lung Transplant, Gleneagles Global Health City, Chennai, Tamil Nadu, India.
Jazyk:	angličtina
Zdroj:	Lung India : official organ of Indian Chest Society [Lung India] 2021 May-Jun; Vol. 38 (3), pp. 216-222.
DOI:	10.4103/lungindia.lungindia_585_20
Abstrakt:	Background: Lung transplantation (LT) has emerged as a definitive cure for a plethora of end-stage lung diseases (ESLDs). With improvements in immune-suppression protocols, the posttransplantation survival rates have gone up. Aim: The study reported the initial experience of the India's single largest lung transplant program on clinicopathological profile, procedures, challenges encountered, and outcomes. Settings and Design: A retrospective analysis was done from data available at three centers of Institute of Heart and Lung Transplant, Gleneagles Global Hospitals across Chennai, Bengaluru, and Mumbai. Materials and Methods: A total of 132 patients underwent lung (single or bilateral) or combined heart and lung transplant between April 2017 and March 2020. All the participants had 30 days' follow-up. Postoperative complications, graft rejection, and 30-day mortality were reported. Kaplan-Meier survival analysis and logistic regression analysis were performed. Statistical Analysis Used: Kaplan-Meier survival and binary logistic regression was performed. Results: Interstitial lung diseases, 65.91%, were the most common diagnosis. Bilateral LT (81.3%) was the most common type of LT performed. Grade III primary graft dysfunction was observed in 16 (12.1%). Distal airway stenosis (21.97%) was the most common complication followed by anastomotic stenosis (14.30%). Gram-negative bacterial sepsis (52%) was the leading cause of death. Cumulative probability of survival at 1 month was 0.85 (95% confidence interval [CI] 0.80-0.92), and at 1 year, it was 0.78 (95% CI, 0.72-0.86). Conclusion: This study establishes the fact that despite multiple challenges, LT is a viable option for selected patients with ESLDs in India and should encourage early referrals to a transplant center. Competing Interests: None
Databáze:	MEDLINE
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