Tunable chitosan-calcium phosphate composites as cell-instructive dental pulp capping agents.

Autor: Osmond MJ; Department of Chemical & Biological Engineering, Colorado School of Mines, Golden, CO, USA., Krebs MD; Department of Chemical & Biological Engineering, Colorado School of Mines, Golden, CO, USA.
Jazyk: angličtina
Zdroj: Journal of biomaterials science. Polymer edition [J Biomater Sci Polym Ed] 2021 Aug; Vol. 32 (11), pp. 1450-1465. Date of Electronic Publication: 2021 Jun 10.
DOI: 10.1080/09205063.2021.1925390
Abstrakt: Dental cavities are the most prevalent, preventable disease worldwide providing a need for robust treatment options to restore both the form and function of decaying teeth. Here is a presentation of a possible regenerative pulp capping agent that can serve to restore tooth function while regenerating healthy dentin tissue over a long period of time. To achieve this goal a material needs to crosslink quickly, be structurally rigid, and support the proliferation and differentiation of stem cells contained within the dental pulp. In this study, calcium phosphate nanoparticles were embedded in polymer hydrogels of carboxymethyl-chitosan and a diglycidyl ether. The particle size, surface, and mechanical properties of these materials were characterized. These composites have moduli up to 3 MPa, support the culture of dental pulp stem cells more than 3 weeks and exhibit osteogenic potential even without osteogenic media. These composites demonstrate a promising potential as the next generation of pulp capping materials.
Databáze: MEDLINE
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