Association between the Persistence of Obesity and the Risk of Gastric Cancer: A Nationwide Population-Based Study.

Autor: Lim JH; Department of Internal Medicine, Healthcare Research Institute, Healthcare System Gangnam Center, Seoul National University Hospital, Seoul, Korea., Shin CM; Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Korea., Han KD; Department of Statistics and Actuarial Science, Soongsil University, Seoul, Korea., Lee SW; College of Medicine, The Catholic University of Korea, Seoul, Korea., Jin EH; Department of Internal Medicine, Healthcare Research Institute, Healthcare System Gangnam Center, Seoul National University Hospital, Seoul, Korea., Choi YJ; Division of Gastroenterology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea., Yoon H; Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Korea., Park YS; Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Korea., Kim N; Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Korea., Lee DH; Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Korea.
Jazyk: angličtina
Zdroj: Cancer research and treatment [Cancer Res Treat] 2022 Jan; Vol. 54 (1), pp. 199-207. Date of Electronic Publication: 2021 May 04.
DOI: 10.4143/crt.2021.130
Abstrakt: Purpose: There remains controversy about relationship between obesity and gastric cancer. We aimed to examine the association using obesity-persistence.
Materials and Methods: We analyzed a nationwide population-based cohort which underwent health check-up between 2009 and 2012. Among them, those who had annual examinations during the last 5 years were selected. Gastric cancer risk was compared between those without obesity during the 5 years (never-obesity group) and those with obesity diagnosis during the 5 years (non-persistent obesity group; persistent obesity group).
Results: Among 2,757,017 individuals, 13,441 developed gastric cancer after median 6.78 years of follow-up. Gastric cancer risk was the highest in persistent obesity group (incidence rate [IR], 0.89/1,000 person-years; hazard ratio [HR], 1.197; 95% confidence interval [CI], 1.117 to 1.284), followed by non-persistent obesity group (IR, 0.83/1,000 person-years; HR, 1.113; 95% CI, 1.056 to 1.172) compared with never-obesity group. In subgroup analysis, this positive relationship was true among those < 65 years old and male. Among heavy-drinkers, the impact of obesity-persistence on the gastric cancer risk far increased (non-persistent obesity: HR, 1.297; 95% CI, 1.094 to 1.538; persistent obesity: HR, 1.351; 95% CI, 1.076 to 1.698).
Conclusion: Obesity-persistence is associated with increased risk of gastric cancer in a dose-response manner, especially among male < 65 years old. The risk raising effect was much stronger among heavy-drinkers.
Databáze: MEDLINE
Externí odkaz: