| Autor: |
Nguyen TTH; Institute of Chemistry, Vietnam Academy of Science and Technology (VAST), Hanoi, Vietnam.; Faculty of Chemistry, Graduate University of Science and Technology, Vietnam Academy of Science and Technology (VAST), Hanoi, Vietnam., Nguyen VT; Institute of Chemistry, Vietnam Academy of Science and Technology (VAST), Hanoi, Vietnam.; Faculty of Chemistry, Graduate University of Science and Technology, Vietnam Academy of Science and Technology (VAST), Hanoi, Vietnam., Van Cuong P; Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST), Hanoi, Vietnam., Nguyen Thanh T; Institute of Chemistry, Vietnam Academy of Science and Technology (VAST), Hanoi, Vietnam.; Faculty of Chemistry, Graduate University of Science and Technology, Vietnam Academy of Science and Technology (VAST), Hanoi, Vietnam., Le Thi TA; Institute of Chemistry, Vietnam Academy of Science and Technology (VAST), Hanoi, Vietnam., Mai Huong DT; Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST), Hanoi, Vietnam., Truong BN; Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST), Hanoi, Vietnam., Litaudon M; French National Centre for Scientific Research, Paris, France., Ninh The S; Institute of Chemistry, Vietnam Academy of Science and Technology (VAST), Hanoi, Vietnam. |
| Abstrakt: |
From the ethyl acetate extract (EtOAc) of the Vietnamese Garcinia mckeaniana leaves, a new flavone 8- C -glycoside 2'',6''-di- O -acetylvitexin ( 1 ), together with six known analogs 2-7 were isolated. Their structures were determined by spectral methods and compared with literature data. In α-glucosidase inhibitory assay, the EtOAc extract and its flavone and biflavone derivatives possessed the significant IC 50 range of 9.17-97.53 µM, as compared with that of the positive control acarbose (249 µM). Flavones and biflavones showed are better than flavone glycosides in both α-glucosidase and acetylcholinesterase inhibitory activities[Formula: see text]. |
