Macrophage Polarization in the Skin Lesion Caused by Neotropical Species of Leishmania sp.

Autor: Sandoval Pacheco CM; Departamento de Patologia, Laboratório de Patologia de Moléstias Infecciosas, Faculdade de Medicina, Universidade de São Paulo, Av. Doutor Arnaldo 455, 01246-903, Cerqueira César, São Paulo, SP, Brazil., Araujo Flores GV; Departamento de Patologia, Laboratório de Patologia de Moléstias Infecciosas, Faculdade de Medicina, Universidade de São Paulo, Av. Doutor Arnaldo 455, 01246-903, Cerqueira César, São Paulo, SP, Brazil., Gonzalez K; Departamento de Parasitología Molecular, Instituto Conmemorativo Gorgas de Estudios de la Salud, Ave. Justo Arosemena, 0816-02593 Calidonia, Panama., de Castro Gomes CM; Departamento de Patologia, Laboratório de Patologia de Moléstias Infecciosas, Faculdade de Medicina, Universidade de São Paulo, Av. Doutor Arnaldo 455, 01246-903, Cerqueira César, São Paulo, SP, Brazil., Passero LFD; São Paulo State University (UNESP), Institute of Biosciences and Institute for Advanced Studies of Ocean, São Vicente, SP, Brazil., Tomokane TY; Departamento de Patologia, Laboratório de Patologia de Moléstias Infecciosas, Faculdade de Medicina, Universidade de São Paulo, Av. Doutor Arnaldo 455, 01246-903, Cerqueira César, São Paulo, SP, Brazil., Sosa-Ochoa W; Departamento de Patologia, Laboratório de Patologia de Moléstias Infecciosas, Faculdade de Medicina, Universidade de São Paulo, Av. Doutor Arnaldo 455, 01246-903, Cerqueira César, São Paulo, SP, Brazil.; Instituto de Investigación en Microbiología, Universidad Nacional Autónoma de Honduras, Tegucigalpa, Honduras., Zúniga C; Departamento de Vigilancia de la Salud, Hospital Escuela, Tegucigalpa, Honduras., Calzada J; Departamento de Parasitología Molecular, Instituto Conmemorativo Gorgas de Estudios de la Salud, Ave. Justo Arosemena, 0816-02593 Calidonia, Panama.; Facultad de Medicina Veterinaria, Universidad de Panamá, Campus Harmodio Arias Madrid, Av. Juan Pablo II, Albrook, Panama., Saldaña A; Departamento de Parasitología Molecular, Instituto Conmemorativo Gorgas de Estudios de la Salud, Ave. Justo Arosemena, 0816-02593 Calidonia, Panama.; Centro de Investigación y Diagnóstico de Enfermedades Parasitarias, Facultad de Medicina, Universidad de Panamá, Ave. Octavio Méndez Pereira, Panama., Corbett CEP; Departamento de Patologia, Laboratório de Patologia de Moléstias Infecciosas, Faculdade de Medicina, Universidade de São Paulo, Av. Doutor Arnaldo 455, 01246-903, Cerqueira César, São Paulo, SP, Brazil., Silveira FT; Departamento de Parasitologia, Instituto Evandro Chagas, Belém, PA, Brazil.; Núcleo de Medicina Tropical, Universidade Federal de Pará, Belém, PA, Brazil., Laurenti MD; Departamento de Patologia, Laboratório de Patologia de Moléstias Infecciosas, Faculdade de Medicina, Universidade de São Paulo, Av. Doutor Arnaldo 455, 01246-903, Cerqueira César, São Paulo, SP, Brazil.
Jazyk: angličtina
Zdroj: Journal of immunology research [J Immunol Res] 2021 Apr 10; Vol. 2021, pp. 5596876. Date of Electronic Publication: 2021 Apr 10 (Print Publication: 2021).
DOI: 10.1155/2021/5596876
Abstrakt: Macrophages play important roles in the innate and acquired immune responses against Leishmania parasites. Depending on the subset and activation status, macrophages may eliminate intracellular parasites; however, these host cells also can offer a safe environment for Leishmania replication. In this sense, the fate of the parasite may be influenced by the phenotype of the infected macrophage, linked to the subtype of classically activated (M1) or alternatively activated (M2) macrophages. In the present study, M1 and M2 macrophage subsets were analyzed by double-staining immunohistochemistry in skin biopsies from patients with American cutaneous leishmaniasis (ACL) caused by L. ( L. ) amazonensis , L. ( V. ) braziliensis , L. ( V. ) panamensis ,and L. ( L. ) infantum chagasi. High number of M1 macrophages was detected in nonulcerated cutaneous leishmaniasis (NUCL) caused by L. ( L. ) infantum chagasi (M1 = 112 ± 12, M2 = 43 ± 12 cells/mm 2 ). On the other side, high density of M2 macrophages was observed in the skin lesions of patients with anergic diffuse cutaneous leishmaniasis (ADCL) (M1 = 195 ± 25, M2 = 616 ± 114), followed by cases of localized cutaneous leishmaniasis (LCL) caused by L . ( L .) amazonensis (M1 = 97 ± 24, M2 = 219 ± 29), L. ( V .) panamensis (M1 = 71 ± 14, M2 = 164 ± 14), and L . ( V .) braziliensis (M1 = 50 ± 13, M2 = 53 ± 10); however, low density of M2 macrophages was observed in NUCL. The data presented herein show the polarization of macrophages in skin lesions caused by different Leishmania species that may be related with the outcome of the disease.
Competing Interests: The authors declare that there is no conflict of interest regarding the publication of this paper.
(Copyright © 2021 Carmen M. Sandoval Pacheco et al.)
Databáze: MEDLINE
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