Longitudinal changes on liver proton density fat fraction differ between liver segments.
| Autor: | Syväri J; Department of Diagnostic and Interventional Radiology, School of Medicine, Technical University of Munich, Munich, Germany., Junker D; Department of Diagnostic and Interventional Radiology, School of Medicine, Technical University of Munich, Munich, Germany., Patzelt L; Department of Diagnostic and Interventional Radiology, School of Medicine, Technical University of Munich, Munich, Germany., Kappo K; Institute for Nutritional Medicine, Else Kroener-Fresenius-Center of Nutritional Medicine, School of Medicine, Technical University of Munich, Munich, Germany., Al Sadat L; Institute for Nutritional Medicine, Else Kroener-Fresenius-Center of Nutritional Medicine, School of Medicine, Technical University of Munich, Munich, Germany., Erfanian S; Institute for Nutritional Medicine, Else Kroener-Fresenius-Center of Nutritional Medicine, School of Medicine, Technical University of Munich, Munich, Germany., Makowski MR; Department of Diagnostic and Interventional Radiology, School of Medicine, Technical University of Munich, Munich, Germany., Hauner H; Institute for Nutritional Medicine, Else Kroener-Fresenius-Center of Nutritional Medicine, School of Medicine, Technical University of Munich, Munich, Germany.; German Center for Diabetes Research, Helmholtz Diabetes Center, Neuherberg, Germany., Karampinos DC; Department of Diagnostic and Interventional Radiology, School of Medicine, Technical University of Munich, Munich, Germany. |
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| Jazyk: | angličtina |
| Zdroj: | Quantitative imaging in medicine and surgery [Quant Imaging Med Surg] 2021 May; Vol. 11 (5), pp. 1701-1709. |
| DOI: | 10.21037/qims-20-873 |
| Abstrakt: | Background: To study the spatial heterogeneity of liver fat fraction changes during a long-term lifestyle intervention study using magnetic resonance imaging (MRI). Methods: Thirty-two subjects underwent two MRI-scans in a span of one year. A chemical shift encoding-based water-fat separation method was applied to measure liver proton density fat fraction (PDFF) maps. The PDFF changes in the two liver lobes and the Couinaud segments were compared with the mean liver PDFF change. Results: The slope of the relationship between mean liver PDFF changes and PDFF liver lobe changes was higher in the right compared to the left lobe (slope Conclusions: Larger PDFF changes in the right liver lobe were observed compared to PDFF changes in the left liver lobe (LLL) in subjects with both increasing and decreasing mean liver PDFF after one year. The results are in line with the existing literature reporting a heterogeneous spatial distribution of liver fat and highlight the need to spatially resolve liver fat fraction changes in longitudinal studies. Competing Interests: Conflicts of Interest: All authors have completed the ICMJE uniform disclosure form (available at http://dx.doi.org/10.21037/qims-20-873). Dr. HH reports grants from German Ministry of Education and Research, during the conduct of the study; Dr. DCK reports grants from European Research Council, grants from Philips Healthcare, during the conduct of the study; Dr. DCK reports grants from European Research Council (No. 677661), grants from Philips Healthcare, grants from German Research Foundation (DFG-SFB824/A9), during the conduct of the study; grants from Philips Healthcare, outside the submitted work. The other authors have no conflicts of interest to declare. (2021 Quantitative Imaging in Medicine and Surgery. All rights reserved.) |
| Databáze: | MEDLINE |
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