Use of pyridoxine hydrochloride in the interruption of lactation in female dogs with pseudopregnancy.
| Autor: | da Silva MC; Departamento de Ciências Agrárias e Ambientais, Universidade Estadual de Santa Cruz - UESC, Ilhéus, BA, Brasil., Guedes PEB; Departamento de Ciências Agrárias e Ambientais, Universidade Estadual de Santa Cruz - UESC, Ilhéus, BA, Brasil., Silva FL; Departamento de Ciências Agrárias e Ambientais, Universidade Estadual de Santa Cruz - UESC, Ilhéus, BA, Brasil., Snoeck PPDN; Departamento de Ciências Agrárias e Ambientais, Universidade Estadual de Santa Cruz - UESC, Ilhéus, BA, Brasil. |
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| Jazyk: | angličtina |
| Zdroj: | Animal reproduction [Anim Reprod] 2021 Mar 31; Vol. 18 (1), pp. e20200062. Date of Electronic Publication: 2021 Mar 31. |
| DOI: | 10.1590/1984-3143-AR2020-0062 |
| Abstrakt: | The aim of this research was to evaluate the use of pyridoxine hydrochloride and its associated side effects in the treatment of pseudopregnancy in female dogs. A total of 40 female dogs, with no defined breed, in non-gestational diestrus, with clinical complaint of milk production were selected. The female dogs were divided into four experimental groups of 10 animals each, treated orally for 20 days with 10mg/kg/day (G1) and 50mg/kg/day (G2) of pyridoxine hydrochloride (vitamin B6), 5μg/kg/day of cabergoline (G3), and with a placebo, in the case of the control group (G4). The effects of the treatments on milk production were investigated, as well as possible systemic side effects, macroscopic uterine and ovarian alterations, and uterine histology. During the investigated period, G2 and G3 were equally efficient (P>0.05) in lactation suppression, differing (P>0.05) from the other groups. There were no systemic side effects or uterine changes associated with administration of the studied drug. Vitamin B6 (50mg/kg) has shown to be a safe and economically viable alternative for lactation interruption in female dogs with pseudopregnancy. Competing Interests: Conflict of interest: The authors have no conflict of interest to declare. |
| Databáze: | MEDLINE |
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