Role of Circulating T Follicular Helper Cells and Stem-Like Memory CD4 + T Cells in the Pathogenesis of HIV-2 Infection and Disease Progression.

Autor:	Ponnan SM; Department of HIV/AIDS, National Institute for Research in Tuberculosis (Indian Council of Medical Research), Chennai, India.; Centre for Infectious Disease Research, Indian Institute of Science, Bangalore, India., Vidyavijayan KK; Department of HIV/AIDS, National Institute for Research in Tuberculosis (Indian Council of Medical Research), Chennai, India., Thiruvengadam K; Department of HIV/AIDS, National Institute for Research in Tuberculosis (Indian Council of Medical Research), Chennai, India., Hilda J N; Department of HIV/AIDS, National Institute for Research in Tuberculosis (Indian Council of Medical Research), Chennai, India., Mathayan M; Centre for Drug Discovery and Development, Sathyabama Institute of Science and Technology, Chennai, India., Murugavel KG; Division of Immunology, YRG Centre for AIDS Research and Education, Chennai, India., Hanna LE; Department of HIV/AIDS, National Institute for Research in Tuberculosis (Indian Council of Medical Research), Chennai, India.
Jazyk:	angličtina
Zdroj:	Frontiers in immunology [Front Immunol] 2021 Apr 16; Vol. 12, pp. 666388. Date of Electronic Publication: 2021 Apr 16 (Print Publication: 2021).
DOI:	10.3389/fimmu.2021.666388
Abstrakt:	CD4 + T cells are critical players in the host adaptive immune response. Emerging evidence suggests that certain CD4 + T cell subsets contribute significantly to the production of neutralizing antibodies and help in the control of virus replication. Circulating T follicular helper cells (Tfh) constitute a key T cell subset that triggers the adaptive immune response and stimulates the production of neutralizing antibodies (NAbs). T cells having stem cell-like property, called stem-like memory T cells (Tscm), constitute another important subset of T cells that play a critical role in slowing the rate of disease progression through the differentiation and expansion of different types of memory cell subsets. However, the role of these immune cell subsets in T cell homeostasis, CD4 + T cell proliferation, and progression of disease, particularly in HIV-2 infection, has not yet been elucidated. The present study involved a detailed evaluation of the different CD4 + T cell subsets in HIV-2 infected persons with a view to understanding the role of these immune cell subsets in the better control of virus replication and delayed disease progression that is characteristic of HIV-2 infection. We observed elevated levels of CD4 + Tfh and CD4 + Tscm cells along with memory and effector T cell abundance in HIV-2 infected individuals. We also found increased frequencies of CXCR5 + CD8 + T cells and CD8 + Tscm cells, as well as memory B cells that are responsible for NAb development in HIV-2 infected persons. Interestingly, we found that the frequency of memory CD4 + T cells as well as memory B cells correlated significantly with neutralizing antibody titers in HIV-2 infected persons. These observations point to a more robust CD4 + T cell response that supports B cell differentiation, antibody production, and CD8 + T cell development in HIV-2 infected persons and contributes to better control of the virus and slower rate of disease progression in these individuals. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2021 Ponnan, Vidyavijayan, Thiruvengadam, Hilda J, Mathayan, Murugavel and Hanna.)
Databáze:	MEDLINE
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