Impact of Treatment Regimens on Antibody Response to the SARS-CoV-2 Coronavirus.
| Autor: | Shang Y; Department of Hematology, Zhongnan Hospital of Wuhan University, Wuhan, China., Liu T; Department of Urology, Zhongnan Hospital of Wuhan University, Wuhan, China.; Center for Evidence-Based and Translational Medicine, Zhongnan Hospital of Wuhan University, Wuhan, China., Li J; Department of Orthopedics, Zhongnan Hospital of Wuhan University, Wuhan, China., Kaweme NM; Department of Hematology, Zhongnan Hospital of Wuhan University, Wuhan, China., Wang X; Department of Urology, Zhongnan Hospital of Wuhan University, Wuhan, China.; Center for Evidence-Based and Translational Medicine, Zhongnan Hospital of Wuhan University, Wuhan, China., Zhou F; Department of Hematology, Zhongnan Hospital of Wuhan University, Wuhan, China. |
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| Jazyk: | angličtina |
| Zdroj: | Frontiers in immunology [Front Immunol] 2021 Apr 15; Vol. 12, pp. 580147. Date of Electronic Publication: 2021 Apr 15 (Print Publication: 2021). |
| DOI: | 10.3389/fimmu.2021.580147 |
| Abstrakt: | The coronavirus disease 2019 (COVID-19) is widely spread and remains a global pandemic. Limited evidence on the systematic evaluation of the impact of treatment regimens on antibody responses exists. Our study aimed to analyze the role of antibody response on prognosis and determine factors influencing the IgG antibodies' seroconversion. A total of 1,111 patients with mild to moderate COVID-19 symptoms admitted to Leishenshan Hospital in Wuhan were retrospectively analyzed. A serologic SARS-CoV-2 IgM/IgG antibody test was performed on all the patients 21 days after the onset of symptoms. Patient clinical characteristics were compared. In the study, 42 patients progressed to critical illness, with 6 mortalities reported while 1,069 patients reported mild to moderate disease. Advanced age ( P = 0.028), gasping ( P < 0.001), dyspnea ( P = 0.024), and IgG negativity ( P = 0.006) were associated with progression to critical illness. The mortality rate in critically ill patients with IgG antibody was 6.45% (95% CI 1.12-22.84%) and 36.36% (95% CI 12.36-68.38%) in patients with no IgG antibody ( P = 0.003). Symptomatic patients were more likely to develop IgG antibody responses than asymptomatic patients. Using univariable analysis, fever ( P < 0.001), gasping ( P = 0.048), cancer ( P < 0.001), cephalosporin ( P = 0.015), and chloroquine/hydroxychloroquine ( P = 0.021) were associated with IgG response. In the multivariable analysis, fever, cancer, cephalosporins, and chloroquine/hydroxychloroquine correlated independently with IgG response. We determined that the absence of SARS-CoV-2 antibody IgG in the convalescent stage had a specific predictive role in critical illness progression. Importantly, risk factors affecting seropositivity were identified, and the effect of antimalarial drugs on antibody response was determined. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2021 Shang, Liu, Li, Kaweme, Wang and Zhou.) |
| Databáze: | MEDLINE |
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