Naturalistic Spike Trains Drive State-Dependent Homeostatic Plasticity in Superficial Layers of Visual Cortex.

Autor:	Chokshi V; The Zanvyl-Krieger Mind/Brain Institute, Johns Hopkins University, Baltimore, MD, United States.; Cell Molecular Developmental Biology and Biophysics (CMDB) Graduate Program, Johns Hopkins University, Baltimore, MD, United States., Grier BD; The Zanvyl-Krieger Mind/Brain Institute, Johns Hopkins University, Baltimore, MD, United States.; The Solomon H. Snyder Department of Neuroscience, Johns Hopkins School of Medicine, Baltimore, MD, United States., Dykman A; The Zanvyl-Krieger Mind/Brain Institute, Johns Hopkins University, Baltimore, MD, United States., Lantz CL; Department of Biology, University of Maryland, College Park, MD, United States., Niebur E; The Zanvyl-Krieger Mind/Brain Institute, Johns Hopkins University, Baltimore, MD, United States.; The Solomon H. Snyder Department of Neuroscience, Johns Hopkins School of Medicine, Baltimore, MD, United States., Quinlan EM; Department of Biology, University of Maryland, College Park, MD, United States.; Neuroscience and Cognitive Science Program, Brain and Behavior Institute, University of Maryland, College Park, MD, United States., Lee HK; The Zanvyl-Krieger Mind/Brain Institute, Johns Hopkins University, Baltimore, MD, United States.; Cell Molecular Developmental Biology and Biophysics (CMDB) Graduate Program, Johns Hopkins University, Baltimore, MD, United States.; The Solomon H. Snyder Department of Neuroscience, Johns Hopkins School of Medicine, Baltimore, MD, United States.; The Kavli Neuroscience Discovery Institute, Johns Hopkins University, Baltimore, MD, United States.
Jazyk:	angličtina
Zdroj:	Frontiers in synaptic neuroscience [Front Synaptic Neurosci] 2021 Apr 15; Vol. 13, pp. 663282. Date of Electronic Publication: 2021 Apr 15 (Print Publication: 2021).
DOI:	10.3389/fnsyn.2021.663282
Abstrakt:	The history of neural activity determines the synaptic plasticity mechanisms employed in the brain. Previous studies report a rapid reduction in the strength of excitatory synapses onto layer 2/3 (L2/3) pyramidal neurons of the primary visual cortex (V1) following two days of dark exposure and subsequent re-exposure to light. The abrupt increase in visually driven activity is predicted to drive homeostatic plasticity, however, the parameters of neural activity that trigger these changes are unknown. To determine this, we first recorded spike trains in vivo from V1 layer 4 (L4) of dark exposed (DE) mice of both sexes that were re-exposed to light through homogeneous or patterned visual stimulation. We found that delivering the spike patterns recorded in vivo to L4 of V1 slices was sufficient to reduce the amplitude of miniature excitatory postsynaptic currents (mEPSCs) of V1 L2/3 neurons in DE mice, but not in slices obtained from normal reared (NR) controls. Unexpectedly, the same stimulation pattern produced an up-regulation of mEPSC amplitudes in V1 L2/3 neurons from mice that received 2 h of light re-exposure (LE). A Poisson spike train exhibiting the same average frequency as the patterns recorded in vivo was equally effective at depressing mEPSC amplitudes in L2/3 neurons in V1 slices prepared from DE mice. Collectively, our results suggest that the history of visual experience modifies the responses of V1 neurons to stimulation and that rapid homeostatic depression of excitatory synapses can be driven by non-patterned input activity. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2021 Chokshi, Grier, Dykman, Lantz, Niebur, Quinlan and Lee.)
Databáze:	MEDLINE
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