Synbiotic sheep milk ice cream reduces chemically induced mouse colon carcinogenesis.

Autor:	Balthazar CF; Department of Food Science and Nutrition, Faculty of Food Engineering, University of Campinas, Campinas, 13083-862, SP, Brazil; Department of Veterinary Hygiene and Technological Processing of Animal Products, Veterinary School, Federal Fluminense University (UFF), Niterói, 24220-000, RJ, Brazil., de Moura NA; Department of Structural and Functional Biology, Institute of Biosciences of Botucatu, São Paulo State University (UNESP), Botucatu, 18618-970, SP, Brazil., Romualdo GR; Department of Structural and Functional Biology, Institute of Biosciences of Botucatu, São Paulo State University (UNESP), Botucatu, 18618-970, SP, Brazil., Rocha RS; Department of Veterinary Hygiene and Technological Processing of Animal Products, Veterinary School, Federal Fluminense University (UFF), Niterói, 24220-000, RJ, Brazil; Department of Food, Federal Institute of Rio de Janeiro (IFRJ), Rio de Janeiro, 20270-021, RJ, Brazil., Pimentel TC; Department of Food Science, Federal Institute of Paraná (IFPR), Paranavaí, 87703-536, Paraná, Brazil., Esmerino EA; Department of Veterinary Hygiene and Technological Processing of Animal Products, Veterinary School, Federal Fluminense University (UFF), Niterói, 24220-000, RJ, Brazil; Department of Food, Federal Institute of Rio de Janeiro (IFRJ), Rio de Janeiro, 20270-021, RJ, Brazil; Department of Food Technology, Rural Federal University of Rio de Janeiro (UFRRJ), Seropédica, 23890-000, RJ, Brazil., Freitas MQ; Department of Veterinary Hygiene and Technological Processing of Animal Products, Veterinary School, Federal Fluminense University (UFF), Niterói, 24220-000, RJ, Brazil., Santillo A; Department of Agriculture, Food, Natural Resources, and Engineering (DAFNE), University of Foggia (UNIFG), Foggia, 71122, Italy., Silva MC; Department of Food, Federal Institute of Rio de Janeiro (IFRJ), Rio de Janeiro, 20270-021, RJ, Brazil., Barbisan LF; Department of Veterinary Hygiene and Technological Processing of Animal Products, Veterinary School, Federal Fluminense University (UFF), Niterói, 24220-000, RJ, Brazil., Cruz AG; Department of Food, Federal Institute of Rio de Janeiro (IFRJ), Rio de Janeiro, 20270-021, RJ, Brazil., Albenzio M; Department of Agriculture, Food, Natural Resources, and Engineering (DAFNE), University of Foggia (UNIFG), Foggia, 71122, Italy. Electronic address: marzia.albenzio@unifg.it.
Jazyk:	angličtina
Zdroj:	Journal of dairy science [J Dairy Sci] 2021 Jul; Vol. 104 (7), pp. 7406-7414. Date of Electronic Publication: 2021 Apr 30.
DOI:	10.3168/jds.2020-19979
Abstrakt:	Sheep dairy products containing prebiotic and probiotic ingredients may have health-promoting properties. Thus, this study evaluated the effects of sheep milk ice cream [conventional full-fat (CONV), full-fat enriched with probiotic (PROB, 100 mg % wt/wt of Lacticaseibacillus casei 01), or nonfat synbiotic (SYNB, Lacticaseibacillus casei 01 and inulin, 10% wt/wt)] on carcinogen-induced colonic crypt cytotoxicity and premalignant lesion development. Male Swiss mice received 2 doses of colon carcinogen azoxymethane (AOM, 15 mg/kg of body weight) at wk 3 and 4. Two weeks before and during AOM administrations (4 wk) mice were treated with CONV, PROB, or SYNB by gavage (10 mL/kg). Mice were euthanized at wk 4 or 25 (n = 5 or 10 mice/group, respectively). At wk 4, a significant reduction in micronucleated colonocytes was observed in PROB and SYNB groups, and a significant decrease in both p53 expression and apoptosis indexes in colonic crypts was observed in SYNB group. At wk 25, both PROB and SYNB interventions reduced the mean number of colonic premalignant lesions. However, only SYNB group showed lower incidence and number of high-grade premalignant lesions in the colonic mucosa. These findings indicate that PROB or SYNB sheep milk ice cream, especially SYNB intervention, can reduce chemically induced mouse colon carcinogenesis. (Copyright © 2021 American Dairy Science Association. Published by Elsevier Inc. All rights reserved.)
Databáze:	MEDLINE
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