Employing core regulatory circuits to define cell identity.

Autor: Almeida N; Centre for Stem Cells and Regenerative Medicine, Guy's Hospital, King's College London, London, UK., Chung MWH; Centre for Stem Cells and Regenerative Medicine, Guy's Hospital, King's College London, London, UK., Drudi EM; Centre for Stem Cells and Regenerative Medicine, Guy's Hospital, King's College London, London, UK., Engquist EN; Centre for Stem Cells and Regenerative Medicine, Guy's Hospital, King's College London, London, UK., Hamrud E; Centre for Stem Cells and Regenerative Medicine, Guy's Hospital, King's College London, London, UK., Isaacson A; Centre for Stem Cells and Regenerative Medicine, Guy's Hospital, King's College London, London, UK., Tsang VSK; Centre for Stem Cells and Regenerative Medicine, Guy's Hospital, King's College London, London, UK., Watt FM; Centre for Stem Cells and Regenerative Medicine, Guy's Hospital, King's College London, London, UK., Spagnoli FM; Centre for Stem Cells and Regenerative Medicine, Guy's Hospital, King's College London, London, UK.
Jazyk: angličtina
Zdroj: The EMBO journal [EMBO J] 2021 May 17; Vol. 40 (10), pp. e106785. Date of Electronic Publication: 2021 May 02.
DOI: 10.15252/embj.2020106785
Abstrakt: The interplay between extrinsic signaling and downstream gene networks controls the establishment of cell identity during development and its maintenance in adult life. Advances in next-generation sequencing and single-cell technologies have revealed additional layers of complexity in cell identity. Here, we review our current understanding of transcription factor (TF) networks as key determinants of cell identity. We discuss the concept of the core regulatory circuit as a set of TFs and interacting factors that together define the gene expression profile of the cell. We propose the core regulatory circuit as a comprehensive conceptual framework for defining cellular identity and discuss its connections to cell function in different contexts.
(© 2021 The Authors. Published under the terms of the CC BY 4.0 license.)
Databáze: MEDLINE
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