Prenatal paraben exposure and atopic dermatitis-related outcomes among children.

Autor: Thürmann L; Molecular Epidemiology Unit, Berlin Institute of Health at Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, associated partner of the German Center for Lung Research (DZL), Berlin, Germany., Herberth G; Department of Environmental Immunology, Helmholtz Centre for Environmental Research-UFZ, Leipzig, Germany., Seiwert B; Department of Analytical Chemistry, Helmholtz Centre for Environmental Research - UFZ, Leipzig, Germany., Schlittenbauer L; Department of Analytical Chemistry, Helmholtz Centre for Environmental Research - UFZ, Leipzig, Germany., Rolle-Kampczyk U; Department of Molecular Systems Biology, Helmholtz Centre for Environmental Research-UFZ, Leipzig, Germany., Röder S; Department of Environmental Immunology, Helmholtz Centre for Environmental Research-UFZ, Leipzig, Germany., Sack U; Institute of Clinical Immunology, Medical Faculty, University Leipzig, Leipzig, Germany., Borte M; Children's Hospital, Municipal Hospital 'St.Georg', Academic Teaching Hospital of the University of Leipzig, Leipzig, Germany., von Bergen M; Department of Molecular Systems Biology, Helmholtz Centre for Environmental Research-UFZ, Leipzig, Germany.; Department of Biochemistry, Faculty of Biosciences, Pharmacy and Psychology, University of Leipzig, Leipzig, Germany., Trump S; Molecular Epidemiology Unit, Berlin Institute of Health at Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, associated partner of the German Center for Lung Research (DZL), Berlin, Germany., Reemtsma T; Department of Analytical Chemistry, Helmholtz Centre for Environmental Research - UFZ, Leipzig, Germany., Lehmann I; Molecular Epidemiology Unit, Berlin Institute of Health at Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, associated partner of the German Center for Lung Research (DZL), Berlin, Germany.
Jazyk: angličtina
Zdroj: Allergy [Allergy] 2021 Oct; Vol. 76 (10), pp. 3122-3132. Date of Electronic Publication: 2021 May 20.
DOI: 10.1111/all.14890
Abstrakt: Background: Parabens, widely used as preservatives in cosmetics, foods, and other consumer products, are suspected of contributing to allergy susceptibility. The detection of parabens in the placenta or amniotic fluid raised concerns about potential health consequences for the child. Recently, an increased asthma risk following prenatal exposure has been reported. Here, we investigated whether prenatal paraben exposure can influence the risk for atopic dermatitis (AD).
Methods: 261 mother-child pairs of the German mother-child study LINA were included in this analysis. Eight paraben species were quantified in maternal urine obtained at gestational week 34. According to the parental report of physician-diagnosed AD from age 1 to 8 years, disease onset, and persistence, childhood AD was classified into four different phenotypes.
Results: 4.6% (n = 12) and 12.3% (n = 32) of the children were classified as having very early-onset AD (until age two) either with or without remission, 11.9% (n = 31) as early-onset (after age two), and 3.1% (n = 8) as childhood-onset AD (after age six). Exposure to ethylparaben and n-butylparaben was associated with an increased risk to develop very early-onset AD without remission (EtP: adj.OR/95% CI:1.44/1.04-2.00,nBuP:adj.OR/95% CI:1.95/1.22-3.12). The effects of both parabens were predominant in children without a history of maternal AD and independent of children's sex.
Conclusion: Prenatal EtP or nBuP exposure may increase children's susceptibility for persistent AD with disease onset at very early age. This association was particularly pronounced in children without a history of maternal AD, indicating that children without a genetic predisposition are more susceptible to paraben exposure.
(© 2021 The Authors. Allergy published by European Academy of Allergy and Clinical Immunology and John Wiley & Sons Ltd.)
Databáze: MEDLINE
Externí odkaz: