The Triple HIT: Perioperative Management of Heparin-Induced Thrombocytopenia Using Plasma Exchange, Intravenous Immunoglobulin, and Protamine Infusion for Left Ventricular Assist Device Implantation.

Autor: Liu VC; Department of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, MN. Electronic address: Liu.Victor@mayo.edu., Klompas AM; Department of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, MN., Stulak JM; Department of Cardiovascular Surgery, Mayo Clinic College of Medicine and Sciences, Rochester, MN., Yalamuri SM; Department of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, MN.
Jazyk: angličtina
Zdroj: Journal of cardiothoracic and vascular anesthesia [J Cardiothorac Vasc Anesth] 2022 Jun; Vol. 36 (6), pp. 1715-1719. Date of Electronic Publication: 2021 Mar 30.
DOI: 10.1053/j.jvca.2021.03.037
Abstrakt: Heparin-induced thrombocytopenia (HIT) is a serious complication in patients exposed to heparin, leading to thrombocytopenia and, potentially, thrombosis. This disorder is challenging in cardiac surgery when anticoagulation for cardiopulmonary bypass is required. Herein a patient with HIT who had active thrombosis and successfully underwent urgent left ventricular assist device implantation managed with plasma exchange, intravenous immunoglobulin, and protamine infusion is described. These therapies reduce the immune response to heparin and minimize thrombosis when heparin reexposure is planned. These approaches to perioperative management of HIT represent an attractive alternative to the use of non-heparin anticoagulants in the cardiac and vascular surgical population.
(Copyright © 2021 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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