Behavioural effects in mice orally exposed to domoic acid or ibotenic acid are influenced by developmental stages and sex differences.

Autor: Sasaki T; Laboratory of Animal Reproduction and Development, Graduate School of Agricultural, Science, Tohoku University, 468-1 Aramaki-Aoba, Aoba-ku, Sendai, Miyagi, 980-8572, Japan., Saito H; Division of Cellular and Molecular Toxicology, Center for Biological Safety and Research, National Institute of Health Sciences, 3-25-26 Tono-machi, Kawasaki-ku, Kawasaki, Kanagawa, 210-9501, Japan., Hiradate Y; Laboratory of Animal Reproduction and Development, Graduate School of Agricultural, Science, Tohoku University, 468-1 Aramaki-Aoba, Aoba-ku, Sendai, Miyagi, 980-8572, Japan., Hara K; Laboratory of Animal Reproduction and Development, Graduate School of Agricultural, Science, Tohoku University, 468-1 Aramaki-Aoba, Aoba-ku, Sendai, Miyagi, 980-8572, Japan., Tanemura K; Laboratory of Animal Reproduction and Development, Graduate School of Agricultural, Science, Tohoku University, 468-1 Aramaki-Aoba, Aoba-ku, Sendai, Miyagi, 980-8572, Japan. Electronic address: kentaro.tanemura.e4@tohoku.ac.jp.
Jazyk: angličtina
Zdroj: Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2021 Jun 18; Vol. 558, pp. 175-182. Date of Electronic Publication: 2021 Apr 28.
DOI: 10.1016/j.bbrc.2021.04.080
Abstrakt: The structure of the brain is dramatically altered during the critical period. Physiological substances (neurotransmitters, hormones, etc.) in the body fluctuate significantly before and after sexual maturation. Therefore, the effect of chemical exposure on the central nervous system often differs depending on the developmental stage and sex. We aimed to compare the behavioural effects that emerged from the administration of chemicals to mice of different life stages (immature or mature) and different sex (male or female). We administered mice with domoic acid (DA), a marine poison, and ibotenic acid (IA), found in poisonous mushrooms. These excitatory amino acids act as agonists for glutamate and are potent neurotoxins. Interestingly, the behavioural effects of these chemicals were completely different. Following DA administration, we observed memory deficits only in groups of male mice treated at maturity. Following IA administration, we observed deviations in emotional behaviour in groups of male mice treated at both immaturity and maturity. In contrast, few characteristic changes were detected in all groups of females. Our results support the theory that the behavioural effects of chemical administration vary considerably with developmental stages and sex. In conclusion, our findings promote better understanding of individual differences in excitatory chemical-induced neurotoxicity and provide evidence for future risk strategies and treatments.
Competing Interests: Declaration of competing interest There are no conflicts of interest to declare.
(Copyright © 2021 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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